In vitro synthesis of infectious DNA of murine leukaemia virus

Ellen Rothenberg, David Smotkin, David Baltimore, Robert A. Weinberg

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

DNA synthesised in vitro by purified virions of murine leukaemia virus is infectious. Neither RNA nor protein is required for infectivity. Transfection with reverse transcriptase product shows a single-hit dose response and results in the production of complete, infectious virus.

Original languageEnglish (US)
Pages (from-to)122-126
Number of pages5
JournalNature
Volume269
Issue number5624
DOIs
StatePublished - 1977
Externally publishedYes

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Murine Leukemia Viruses
RNA-Directed DNA Polymerase
Virion
Transfection
RNA
Viruses
DNA
Proteins
In Vitro Techniques

ASJC Scopus subject areas

  • General

Cite this

Rothenberg, E., Smotkin, D., Baltimore, D., & Weinberg, R. A. (1977). In vitro synthesis of infectious DNA of murine leukaemia virus. Nature, 269(5624), 122-126. https://doi.org/10.1038/269122a0

In vitro synthesis of infectious DNA of murine leukaemia virus. / Rothenberg, Ellen; Smotkin, David; Baltimore, David; Weinberg, Robert A.

In: Nature, Vol. 269, No. 5624, 1977, p. 122-126.

Research output: Contribution to journalArticle

Rothenberg, E, Smotkin, D, Baltimore, D & Weinberg, RA 1977, 'In vitro synthesis of infectious DNA of murine leukaemia virus', Nature, vol. 269, no. 5624, pp. 122-126. https://doi.org/10.1038/269122a0
Rothenberg, Ellen ; Smotkin, David ; Baltimore, David ; Weinberg, Robert A. / In vitro synthesis of infectious DNA of murine leukaemia virus. In: Nature. 1977 ; Vol. 269, No. 5624. pp. 122-126.
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