In vitro synthesis of infectious DNA of murine leukaemia virus

Ellen Rothenberg; David Smotkin; David Baltimore; Robert A. Weinberg

doi:10.1038/269122a0

In vitro synthesis of infectious DNA of murine leukaemia virus

Ellen Rothenberg, David Smotkin, David Baltimore, Robert A. Weinberg

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

DNA synthesised in vitro by purified virions of murine leukaemia virus is infectious. Neither RNA nor protein is required for infectivity. Transfection with reverse transcriptase product shows a single-hit dose response and results in the production of complete, infectious virus.

Original language	English (US)
Pages (from-to)	122-126
Number of pages	5
Journal	Nature
Volume	269
Issue number	5624
DOIs	https://doi.org/10.1038/269122a0
State	Published - Dec 1 1977
Externally published	Yes

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title = "In vitro synthesis of infectious DNA of murine leukaemia virus",

abstract = "DNA synthesised in vitro by purified virions of murine leukaemia virus is infectious. Neither RNA nor protein is required for infectivity. Transfection with reverse transcriptase product shows a single-hit dose response and results in the production of complete, infectious virus.",

author = "Ellen Rothenberg and David Smotkin and David Baltimore and Weinberg, {Robert A.}",

year = "1977",

month = dec,

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doi = "10.1038/269122a0",

language = "English (US)",

volume = "269",

pages = "122--126",

journal = "Nature",

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T1 - In vitro synthesis of infectious DNA of murine leukaemia virus

AU - Rothenberg, Ellen

AU - Smotkin, David

AU - Baltimore, David

AU - Weinberg, Robert A.

PY - 1977/12/1

Y1 - 1977/12/1

N2 - DNA synthesised in vitro by purified virions of murine leukaemia virus is infectious. Neither RNA nor protein is required for infectivity. Transfection with reverse transcriptase product shows a single-hit dose response and results in the production of complete, infectious virus.

AB - DNA synthesised in vitro by purified virions of murine leukaemia virus is infectious. Neither RNA nor protein is required for infectivity. Transfection with reverse transcriptase product shows a single-hit dose response and results in the production of complete, infectious virus.

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JO - Nature

JF - Nature

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In vitro synthesis of infectious DNA of murine leukaemia virus

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