In vitro synthesis of infectious DNA of murine leukaemia virus

Ellen Rothenberg; David Smotkin; David Baltimore; Robert A. Weinberg

doi:10.1038/269122a0

In vitro synthesis of infectious DNA of murine leukaemia virus

Ellen Rothenberg, David Smotkin, David Baltimore, Robert A. Weinberg

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53 Scopus citations

Abstract

DNA synthesised in vitro by purified virions of murine leukaemia virus is infectious. Neither RNA nor protein is required for infectivity. Transfection with reverse transcriptase product shows a single-hit dose response and results in the production of complete, infectious virus.

Original language	English (US)
Pages (from-to)	122-126
Number of pages	5
Journal	Nature
Volume	269
Issue number	5624
DOIs	https://doi.org/10.1038/269122a0
State	Published - 1977
Externally published	Yes

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title = "In vitro synthesis of infectious DNA of murine leukaemia virus",

abstract = "DNA synthesised in vitro by purified virions of murine leukaemia virus is infectious. Neither RNA nor protein is required for infectivity. Transfection with reverse transcriptase product shows a single-hit dose response and results in the production of complete, infectious virus.",

author = "Ellen Rothenberg and David Smotkin and David Baltimore and Weinberg, {Robert A.}",

year = "1977",

doi = "10.1038/269122a0",

language = "English (US)",

volume = "269",

pages = "122--126",

journal = "Nature",

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number = "5624",

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T1 - In vitro synthesis of infectious DNA of murine leukaemia virus

AU - Rothenberg, Ellen

AU - Smotkin, David

AU - Baltimore, David

AU - Weinberg, Robert A.

PY - 1977

Y1 - 1977

N2 - DNA synthesised in vitro by purified virions of murine leukaemia virus is infectious. Neither RNA nor protein is required for infectivity. Transfection with reverse transcriptase product shows a single-hit dose response and results in the production of complete, infectious virus.

AB - DNA synthesised in vitro by purified virions of murine leukaemia virus is infectious. Neither RNA nor protein is required for infectivity. Transfection with reverse transcriptase product shows a single-hit dose response and results in the production of complete, infectious virus.

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U2 - 10.1038/269122a0

DO - 10.1038/269122a0

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VL - 269

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JO - Nature

JF - Nature

IS - 5624

ER -

In vitro synthesis of infectious DNA of murine leukaemia virus

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