In vitro synthesis of infectious DNA of murine leukaemia virus

Ellen Rothenberg, David Smotkin, David Baltimore, Robert A. Weinberg

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Abstract

DNA synthesised in vitro by purified virions of murine leukaemia virus is infectious. Neither RNA nor protein is required for infectivity. Transfection with reverse transcriptase product shows a single-hit dose response and results in the production of complete, infectious virus.

Original languageEnglish (US)
Pages (from-to)122-126
Number of pages5
JournalNature
Volume269
Issue number5624
DOIs
Publication statusPublished - Dec 1 1977
Externally publishedYes

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Cite this

Rothenberg, E., Smotkin, D., Baltimore, D., & Weinberg, R. A. (1977). In vitro synthesis of infectious DNA of murine leukaemia virus. Nature, 269(5624), 122-126. https://doi.org/10.1038/269122a0