In vitro atrial septal ablation using high-intensity focused ultrasound

Yasuyoshi Takei; Robert Muratore; Andrew Kalisz; Kazue Okajima; Kohei Fujimoto; Takuya Hasegawa; Kotaro Arai; Yelena Rekhtman; Grace Berry; Marco R. Di Tullio; Shunichi Homma

doi:10.1016/j.echo.2011.12.010

In vitro atrial septal ablation using high-intensity focused ultrasound

Yasuyoshi Takei, Robert Muratore, Andrew Kalisz, Kazue Okajima, Kohei Fujimoto, Takuya Hasegawa, Kotaro Arai, Yelena Rekhtman, Grace Berry, Marco R. Di Tullio, Shunichi Homma

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Background: High-intensity focused ultrasound (HIFU) has been applied clinically as a noninvasive therapeutic tool. Atrial septostomy is a palliative treatment for pulmonary artery hypertension. The purpose of this study was to assess the feasibility of atrial septal ablation in vitro using HIFU. Methods: Fourteen sections of atrial septum from pig hearts were treated. Focused ultrasound energy was applied with an operating frequency of 5.25 MHz at the nominal focal point intensity of 4.0 kW/cm ² for 0.4 sec in 1-sec intervals. Results: Lesions were created with ultrasonic exposures ranging from 40 to 120 pulses. There were significant relationships between HIFU exposure time and lesion area on the exposed site (R ² = 0.3389, P <.0001) and lesion volume (R ² = 0.6161, P <.0001). Conclusions: HIFU has the potential to create focal perforations without direct tissue contact. This method may prove useful for noninvasive atrial septostomy.

Original language	English (US)
Pages (from-to)	467-472
Number of pages	6
Journal	Journal of the American Society of Echocardiography
Volume	25
Issue number	4
DOIs	https://doi.org/10.1016/j.echo.2011.12.010
State	Published - Apr 2012
Externally published	Yes

Keywords

Atrial septum
High-intensity focused ultrasound
Pulmonary artery hypertension
Therapeutic ultrasound

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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10.1016/j.echo.2011.12.010

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title = "In vitro atrial septal ablation using high-intensity focused ultrasound",

abstract = "Background: High-intensity focused ultrasound (HIFU) has been applied clinically as a noninvasive therapeutic tool. Atrial septostomy is a palliative treatment for pulmonary artery hypertension. The purpose of this study was to assess the feasibility of atrial septal ablation in vitro using HIFU. Methods: Fourteen sections of atrial septum from pig hearts were treated. Focused ultrasound energy was applied with an operating frequency of 5.25 MHz at the nominal focal point intensity of 4.0 kW/cm 2 for 0.4 sec in 1-sec intervals. Results: Lesions were created with ultrasonic exposures ranging from 40 to 120 pulses. There were significant relationships between HIFU exposure time and lesion area on the exposed site (R 2 = 0.3389, P <.0001) and lesion volume (R 2 = 0.6161, P <.0001). Conclusions: HIFU has the potential to create focal perforations without direct tissue contact. This method may prove useful for noninvasive atrial septostomy.",

keywords = "Atrial septum, High-intensity focused ultrasound, Pulmonary artery hypertension, Therapeutic ultrasound",

author = "Yasuyoshi Takei and Robert Muratore and Andrew Kalisz and Kazue Okajima and Kohei Fujimoto and Takuya Hasegawa and Kotaro Arai and Yelena Rekhtman and Grace Berry and {Di Tullio}, {Marco R.} and Shunichi Homma",

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doi = "10.1016/j.echo.2011.12.010",

language = "English (US)",

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T1 - In vitro atrial septal ablation using high-intensity focused ultrasound

AU - Takei, Yasuyoshi

AU - Muratore, Robert

AU - Kalisz, Andrew

AU - Okajima, Kazue

AU - Fujimoto, Kohei

AU - Hasegawa, Takuya

AU - Arai, Kotaro

AU - Rekhtman, Yelena

AU - Berry, Grace

AU - Di Tullio, Marco R.

AU - Homma, Shunichi

PY - 2012/4

Y1 - 2012/4

N2 - Background: High-intensity focused ultrasound (HIFU) has been applied clinically as a noninvasive therapeutic tool. Atrial septostomy is a palliative treatment for pulmonary artery hypertension. The purpose of this study was to assess the feasibility of atrial septal ablation in vitro using HIFU. Methods: Fourteen sections of atrial septum from pig hearts were treated. Focused ultrasound energy was applied with an operating frequency of 5.25 MHz at the nominal focal point intensity of 4.0 kW/cm 2 for 0.4 sec in 1-sec intervals. Results: Lesions were created with ultrasonic exposures ranging from 40 to 120 pulses. There were significant relationships between HIFU exposure time and lesion area on the exposed site (R 2 = 0.3389, P <.0001) and lesion volume (R 2 = 0.6161, P <.0001). Conclusions: HIFU has the potential to create focal perforations without direct tissue contact. This method may prove useful for noninvasive atrial septostomy.

AB - Background: High-intensity focused ultrasound (HIFU) has been applied clinically as a noninvasive therapeutic tool. Atrial septostomy is a palliative treatment for pulmonary artery hypertension. The purpose of this study was to assess the feasibility of atrial septal ablation in vitro using HIFU. Methods: Fourteen sections of atrial septum from pig hearts were treated. Focused ultrasound energy was applied with an operating frequency of 5.25 MHz at the nominal focal point intensity of 4.0 kW/cm 2 for 0.4 sec in 1-sec intervals. Results: Lesions were created with ultrasonic exposures ranging from 40 to 120 pulses. There were significant relationships between HIFU exposure time and lesion area on the exposed site (R 2 = 0.3389, P <.0001) and lesion volume (R 2 = 0.6161, P <.0001). Conclusions: HIFU has the potential to create focal perforations without direct tissue contact. This method may prove useful for noninvasive atrial septostomy.

KW - Atrial septum

KW - High-intensity focused ultrasound

KW - Pulmonary artery hypertension

KW - Therapeutic ultrasound

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In vitro atrial septal ablation using high-intensity focused ultrasound

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Keywords

ASJC Scopus subject areas

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