We have performed in situ hybridization of a probe for the λ IGLC constant region to metaphase spreads from two DiGeorge syndrome (DGS)-relaled chromosomal rearrangements with breakpoints in 22qll. In this study we have demonstrated that the breakpoints are proximal to the λ IGLC constant region cluster. Thus, at the molecular level. DGS-related breakpoints can be distinguished from the 22ql 1 breakpoint of CML, but not from the 8:22 translocation of Burkitt lymphoma or from the 21:22 translocations that we have previously studied.
ASJC Scopus subject areas
- Molecular Biology