In situ hybridization and translocation breakpoint mapping

III. Digeorge syndrome with partial monosomy of chromosome 22

L. A. Cannizzaro, B. S. Emanuel

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We have performed in situ hybridization of a probe for the λ IGLC constant region to metaphase spreads from two DiGeorge syndrome (DGS)-relaled chromosomal rearrangements with breakpoints in 22qll. In this study we have demonstrated that the breakpoints are proximal to the λ IGLC constant region cluster. Thus, at the molecular level. DGS-related breakpoints can be distinguished from the 22ql 1 breakpoint of CML, but not from the 8:22 translocation of Burkitt lymphoma or from the 21:22 translocations that we have previously studied.

Original languageEnglish (US)
Pages (from-to)179-183
Number of pages5
JournalCytogenetic and Genome Research
Volume39
Issue number3
DOIs
StatePublished - 1985
Externally publishedYes

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DiGeorge Syndrome
Chromosomes, Human, Pair 22
Chromosome Deletion
In Situ Hybridization
Burkitt Lymphoma
Metaphase

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Genetics(clinical)
  • Cell Biology

Cite this

In situ hybridization and translocation breakpoint mapping : III. Digeorge syndrome with partial monosomy of chromosome 22. / Cannizzaro, L. A.; Emanuel, B. S.

In: Cytogenetic and Genome Research, Vol. 39, No. 3, 1985, p. 179-183.

Research output: Contribution to journalArticle

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