In situ hybridization and translocation breakpoint mapping: III. Digeorge syndrome with partial monosomy of chromosome 22

L. A. Cannizzaro; B. S. Emanuel

doi:10.1159/000132131

In situ hybridization and translocation breakpoint mapping: III. Digeorge syndrome with partial monosomy of chromosome 22

L. A. Cannizzaro, B. S. Emanuel

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Abstract

We have performed in situ hybridization of a probe for the λ IGLC constant region to metaphase spreads from two DiGeorge syndrome (DGS)-relaled chromosomal rearrangements with breakpoints in 22qll. In this study we have demonstrated that the breakpoints are proximal to the λ IGLC constant region cluster. Thus, at the molecular level. DGS-related breakpoints can be distinguished from the 22ql 1 breakpoint of CML, but not from the 8:22 translocation of Burkitt lymphoma or from the 21:22 translocations that we have previously studied.

Original language	English (US)
Pages (from-to)	179-183
Number of pages	5
Journal	Cytogenetics and Cell Genetics
Volume	39
Issue number	3
DOIs	https://doi.org/10.1159/000132131
State	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

Genetics
Cell Biology

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title = "In situ hybridization and translocation breakpoint mapping: III. Digeorge syndrome with partial monosomy of chromosome 22",

abstract = "We have performed in situ hybridization of a probe for the λ IGLC constant region to metaphase spreads from two DiGeorge syndrome (DGS)-relaled chromosomal rearrangements with breakpoints in 22qll. In this study we have demonstrated that the breakpoints are proximal to the λ IGLC constant region cluster. Thus, at the molecular level. DGS-related breakpoints can be distinguished from the 22ql 1 breakpoint of CML, but not from the 8:22 translocation of Burkitt lymphoma or from the 21:22 translocations that we have previously studied.",

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year = "1985",

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AU - Emanuel, B. S.

PY - 1985

Y1 - 1985

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AB - We have performed in situ hybridization of a probe for the λ IGLC constant region to metaphase spreads from two DiGeorge syndrome (DGS)-relaled chromosomal rearrangements with breakpoints in 22qll. In this study we have demonstrated that the breakpoints are proximal to the λ IGLC constant region cluster. Thus, at the molecular level. DGS-related breakpoints can be distinguished from the 22ql 1 breakpoint of CML, but not from the 8:22 translocation of Burkitt lymphoma or from the 21:22 translocations that we have previously studied.

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In situ hybridization and translocation breakpoint mapping: III. Digeorge syndrome with partial monosomy of chromosome 22

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