In situ hybridization and translocation breakpoint mapping. II. Two unusual t(21;22) translocations

L. A. Cannizzaro; M. M. Aronson; B. S. Emanuel

In situ hybridization and translocation breakpoint mapping. II. Two unusual t(21;22) translocations

L. A. Cannizzaro, M. M. Aronson, B. S. Emanuel

Research output: Contribution to journal › Article › peer-review

Abstract

Using a combination of banding techniques, we examined two atypical 21;22 translocations, 46,XX or XY,t(21;22)(p11;q11). In situ chromosomal hybridization of a probe for the constant region of the lambda light chain locus demonstrated that the 22q 11 breakpoints of both rearrangements were proximal to the Cλ gene cluster. These studies permitted us to distinguish the 22q11 breakpoints of these translocations from the breakpoint of the 22q- chromosome of chronic mylogenous leukemia.

Original language	English (US)
Pages (from-to)	173-178
Number of pages	6
Journal	Cytogenetics and Cell Genetics
Volume	39
Issue number	3
State	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

Genetics
Cell Biology

Cite this

@article{fc7ec89435ae4227a0af0a41819a7ad6,

title = "In situ hybridization and translocation breakpoint mapping. II. Two unusual t(21;22) translocations",

abstract = "Using a combination of banding techniques, we examined two atypical 21;22 translocations, 46,XX or XY,t(21;22)(p11;q11). In situ chromosomal hybridization of a probe for the constant region of the lambda light chain locus demonstrated that the 22q 11 breakpoints of both rearrangements were proximal to the Cλ gene cluster. These studies permitted us to distinguish the 22q11 breakpoints of these translocations from the breakpoint of the 22q- chromosome of chronic mylogenous leukemia.",

author = "Cannizzaro, {L. A.} and Aronson, {M. M.} and Emanuel, {B. S.}",

year = "1985",

language = "English (US)",

volume = "39",

pages = "173--178",

journal = "Cytogenetics and Cell Genetics",

issn = "0301-0171",

publisher = "S. Karger AG",

number = "3",

}

TY - JOUR

T1 - In situ hybridization and translocation breakpoint mapping. II. Two unusual t(21;22) translocations

AU - Cannizzaro, L. A.

AU - Aronson, M. M.

AU - Emanuel, B. S.

PY - 1985

Y1 - 1985

N2 - Using a combination of banding techniques, we examined two atypical 21;22 translocations, 46,XX or XY,t(21;22)(p11;q11). In situ chromosomal hybridization of a probe for the constant region of the lambda light chain locus demonstrated that the 22q 11 breakpoints of both rearrangements were proximal to the Cλ gene cluster. These studies permitted us to distinguish the 22q11 breakpoints of these translocations from the breakpoint of the 22q- chromosome of chronic mylogenous leukemia.

AB - Using a combination of banding techniques, we examined two atypical 21;22 translocations, 46,XX or XY,t(21;22)(p11;q11). In situ chromosomal hybridization of a probe for the constant region of the lambda light chain locus demonstrated that the 22q 11 breakpoints of both rearrangements were proximal to the Cλ gene cluster. These studies permitted us to distinguish the 22q11 breakpoints of these translocations from the breakpoint of the 22q- chromosome of chronic mylogenous leukemia.

UR - http://www.scopus.com/inward/record.url?scp=0022236401&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022236401&partnerID=8YFLogxK

M3 - Article

C2 - 3930156

AN - SCOPUS:0022236401

SN - 0301-0171

VL - 39

SP - 173

EP - 178

JO - Cytogenetics and Cell Genetics

JF - Cytogenetics and Cell Genetics

IS - 3

ER -

In situ hybridization and translocation breakpoint mapping. II. Two unusual t(21;22) translocations

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this