In silico comparative analysis of KRAS mutations at codons 12 and 13: Structural modifications of P-Loop, switch I&II regions preventing GTP hydrolysis

Medicine & Life Sciences

• AAA Domain 100%
• Guanosine Triphosphate 73%
• Codon 68%
• Computer Simulation 65%
• Hydrolysis 64%
• Mutation 39%
• Mutant Proteins 29%
• Glycine 28%
• Hydrophobic and Hydrophilic Interactions 15%
• Protein Binding 13%
• United States Food and Drug Administration 13%
• Computational Biology 13%
• Catalytic Domain 12%
• Phosphates 12%
• Proteins 10%
• Clinical Trials 9%
• Neoplasms 4%

Engineering & Materials Science

• Hydrolysis 83%
• Proteins 63%
• Molecules 50%
• Switches 49%
• Amino acids 41%
• Protein Binding 28%
• Hydrophobicity 22%
• Conformations 21%
• Phosphates 19%
• Bioinformatics 18%