In search of an "autophagomometer"

David C. Rubinsztein, Ana Maria Cuervo, Brinda Ravikumar, Sovan Sarkar, Viktor Korolchuk, Susmita Kaushik, Daniel J. Klionsky

Research output: Contribution to journalReview article

392 Scopus citations

Abstract

Recent years have seen the realization that macroautophagy (which we will call autophagy) is not only important in yeast but is necessary for diverse functions in plants and animals. Importantly, autophagy can have an impact on human pathologies including infectious diseases, cancers, and neurodegenerative conditions.1 Thus, we need to be able to measure autophagy accurately in order to understand how it can be regulated physiologically and with exogenous agents.

Original languageEnglish (US)
Pages (from-to)585-589
Number of pages5
JournalAutophagy
Volume5
Issue number5
DOIs
StatePublished - Jul 1 2009

Keywords

  • Assay
  • Autophagy
  • Flux
  • LC3
  • Synthesis

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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    Rubinsztein, D. C., Cuervo, A. M., Ravikumar, B., Sarkar, S., Korolchuk, V., Kaushik, S., & Klionsky, D. J. (2009). In search of an "autophagomometer". Autophagy, 5(5), 585-589. https://doi.org/10.4161/auto.5.5.8823