Improving pancreas graft utilization through importation

Julia Torabi, Juan P. Rocca, Krystina Choinski, Katherine Lorenzen, Camille Yongue, Michelle L. Lubetzsky, Melvon E. Herbert, Attasit Chokechanachaisakul, Maria Ajaimy, Layla Kamal, Enver Akalin, Milan Kinkhabwala, Jay A. Graham

Research output: Contribution to journalArticle

Abstract

Background: We analyze our outcomes utilizing imported allografts as a strategy to shorten wait list time for pancreas transplantation. Methods: This is an observational retrospective cohort of 26 recipients who received either a locally procured (n = 16) or an imported pancreas graft (n = 10) at our center between January 2014 and May 2017. Wait list times of this cohort were compared to UNOS Region 9 (New York State and Western Vermont). Hospital financial data were also reviewed to analyze the cost-effectiveness of this strategy. Results: Imported pancreas grafts had significantly increased cold ischemia times (CIT) and peak lipase (PL) levels compared to locally procured grafts (CIT 827 vs 497 minutes; P =.001, PL 563 vs 157 u/L; P =.023, respectively). There were no differences in graft or patient survival. The median wait time was significantly lower for simultaneous kidney-pancreas transplants at our center (518 days, n = 21) compared to Region 9 (1001 days, n = 65) P =.038. Despite financial concerns, the cost of transport for imported grafts was offset by lower standard acquisition costs. Conclusions: Imported pancreas grafts may be a cost-effective strategy to increase organ utilization and shorten wait times in regions with longer waiting times.

Original languageEnglish (US)
Article numbere13154
JournalClinical Transplantation
Volume32
Issue number1
DOIs
StatePublished - Jan 1 2018

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Keywords

  • organ acceptance
  • organ procurement
  • Organ Procurement and Transplantation Network
  • organ procurement organization

ASJC Scopus subject areas

  • Transplantation

Cite this

Torabi, J., Rocca, J. P., Choinski, K., Lorenzen, K., Yongue, C., Lubetzsky, M. L., Herbert, M. E., Chokechanachaisakul, A., Ajaimy, M., Kamal, L., Akalin, E., Kinkhabwala, M., & Graham, J. A. (2018). Improving pancreas graft utilization through importation. Clinical Transplantation, 32(1), [e13154]. https://doi.org/10.1111/ctr.13154