Improving AML Classification Using Splicing Signatures

Research output: Contribution to journalComment/debatepeer-review

Abstract

Mutations in spliceosomal components are prevalent in myelodysplastic syndromes, but less so in acute myeloid leukemia (AML). However, aberrant splicing is prolific in AML, suggesting deregulated splicing could contribute broadly to tumorigenesis. Elevated stress responses correlate with splicing dysfunction across myeloid malignancies, representing potentially novel therapeutic targets.See related article by Anande et al., p. 3597.

Original languageEnglish (US)
Pages (from-to)3503-3504
Number of pages2
JournalClinical Cancer Research
Volume26
Issue number14
DOIs
StatePublished - Jul 15 2020

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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