Improving AML Classification Using Splicing Signatures

Teresa V. Bowman

doi:10.1158/1078-0432.CCR-20-1021

Improving AML Classification Using Splicing Signatures

Teresa V. Bowman

Developmental & Molecular Biology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Mutations in spliceosomal components are prevalent in myelodysplastic syndromes, but less so in acute myeloid leukemia (AML). However, aberrant splicing is prolific in AML, suggesting deregulated splicing could contribute broadly to tumorigenesis. Elevated stress responses correlate with splicing dysfunction across myeloid malignancies, representing potentially novel therapeutic targets.

Original language	English (US)
Pages (from-to)	3503-3504
Number of pages	2
Journal	Clinical Cancer Research
Volume	26
Issue number	14
DOIs	https://doi.org/10.1158/1078-0432.CCR-20-1021
State	Published - Jul 15 2020

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1158/1078-0432.CCR-20-1021

Cite this

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title = "Improving AML Classification Using Splicing Signatures",

abstract = "Mutations in spliceosomal components are prevalent in myelodysplastic syndromes, but less so in acute myeloid leukemia (AML). However, aberrant splicing is prolific in AML, suggesting deregulated splicing could contribute broadly to tumorigenesis. Elevated stress responses correlate with splicing dysfunction across myeloid malignancies, representing potentially novel therapeutic targets.",

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year = "2020",

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AB - Mutations in spliceosomal components are prevalent in myelodysplastic syndromes, but less so in acute myeloid leukemia (AML). However, aberrant splicing is prolific in AML, suggesting deregulated splicing could contribute broadly to tumorigenesis. Elevated stress responses correlate with splicing dysfunction across myeloid malignancies, representing potentially novel therapeutic targets.

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JO - Clinical Cancer Research

JF - Clinical Cancer Research

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ER -

Improving AML Classification Using Splicing Signatures

Abstract

ASJC Scopus subject areas

UN SDGs

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