Improved response of a murine fibrosarcoma (meth-A) to interstitial radiation when combined with hyperthermia

C. R. Moorthy, E. W. Hahn, J. H. Kim, S. M. Feingold, A. A. Alfieri, B. S. Hilaris

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Removable Iridium-192 implants provided a dose of 10 Gy/day or 41.5 cGy/hr at 0.5 cm from the center of 1.0 cm diameter tumors. The total radiation (x) alone was 20, 40 or 60 Gy, representing 2, 4, or 6 days of continuous radiation. The doses used for the combined treatments at elevated temperatures were 10, 20 or 30 Gy. The local tumor hyperthermia (LTH) treatment (43.6 for 35 min, water bath) was administered once for each 10 Gy of dose. The combined radiation + LTH was clearly superior to that achieved with radiation or LTH alone and yielded Thermal Enhancement Ratios (TER) of 3.4-3.9. Local tumor control rate was 67% and 89% for the 20 and 30 Gy x + LTH groups, respectively. A comparison of the results obtained in this study with those of earlier studies on the same tumor system indicate that the effects of Iridium-192 alone on this rapidly proliferating t0mor were comparable to similar total doses of fractionated external beam radiation. Iridium + LTH produced a tumor response comparable to that achieved with external fractionated radiation + LTH. Combined treatment effect of elevated temperature appears to be less dose rate dependent in the range of 40 cGy/hr to 100 cGy/min and more dependent upon total dose accumulation.

Original languageEnglish (US)
Pages (from-to)2145-2148
Number of pages4
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume10
Issue number11
DOIs
StatePublished - 1984
Externally publishedYes

Fingerprint

hyperthermia
Fibrosarcoma
interstitials
Fever
tumors
Induced Hyperthermia
Radiation
radiation
Neoplasms
Iridium
dosage
iridium
Temperature
Baths
continuous radiation
baths
Therapeutics
Hot Temperature
temperature
Water

Keywords

  • Brachytherapy
  • Hyperthermia
  • Interstitial therapy
  • Iridium-192

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Improved response of a murine fibrosarcoma (meth-A) to interstitial radiation when combined with hyperthermia. / Moorthy, C. R.; Hahn, E. W.; Kim, J. H.; Feingold, S. M.; Alfieri, A. A.; Hilaris, B. S.

In: International Journal of Radiation Oncology, Biology, Physics, Vol. 10, No. 11, 1984, p. 2145-2148.

Research output: Contribution to journalArticle

Moorthy, C. R. ; Hahn, E. W. ; Kim, J. H. ; Feingold, S. M. ; Alfieri, A. A. ; Hilaris, B. S. / Improved response of a murine fibrosarcoma (meth-A) to interstitial radiation when combined with hyperthermia. In: International Journal of Radiation Oncology, Biology, Physics. 1984 ; Vol. 10, No. 11. pp. 2145-2148.
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