Improved outcomes after blastocyst-stage frozen-thawed embryo transfers compared with cleavage stage: a Society for Assisted Reproductive Technologies Clinical Outcomes Reporting System study

Emily C. Holden, Banafsheh N. Kashani, Sara S. Morelli, Donald Alderson, Sangita K. Jindal, Pamela A. Ohman-Strickland, Peter G. McGovern

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To investigate whether there is a difference in obstetrical and perinatal outcomes in blastocyst frozen-thawed embryo transfers (FETs) compared with cleavage-stage FET. Design: A retrospective cohort study. Setting: Not applicable. Patient(s): Women undergoing autologous FETs at either the blastocyst stage (n = 118,572) or the cleavage stage (n = 117,619) reported to the Society for Assisted Reproductive Technology in the years 2004–2013. Intervention(s): None. Main Outcome Measure(s): Live birth, gestational age, birth weight, miscarriage. Result(s): After controlling for confounders, there were a 49% increased odds of live birth after blastocyst-stage FET compared with cleavage-stage FET (odds ratio [OR] = 1.49; 95% confidence interval [CI], 1.44, 1.54). Additionally, blastocyst FET was associated with a 68% (OR = 1.68; 95% CI, 1.63, 1.74) increased odds of clinical pregnancy and an 7% (OR = 0.93; 95% CI, 0.88, 0.92) decreased odds of miscarriage. There was also a 16% increased odds of preterm delivery (OR = 1.16; 95% CI, 1.06, 1.27) after blastocyst FET but no difference in birth weights. Conclusion(s): In patients undergoing FET, blastocyst-stage transfer is associated with higher live-birth rates when compared with cleavage-stage transfers. Furthermore, perinatal outcomes are similar between the groups.

Original languageEnglish (US)
Pages (from-to)89-94.e2
JournalFertility and Sterility
Volume110
Issue number1
DOIs
StatePublished - Jul 1 2018
Externally publishedYes

Fingerprint

Assisted Reproductive Techniques
Embryo Transfer
Blastocyst
Live Birth
Odds Ratio
Confidence Intervals
Spontaneous Abortion
Birth Weight
Birth Rate
Gestational Age
Cohort Studies
Retrospective Studies
Outcome Assessment (Health Care)
Pregnancy

Keywords

  • Blastocyst
  • cleavage
  • frozen embryo transfer

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Improved outcomes after blastocyst-stage frozen-thawed embryo transfers compared with cleavage stage : a Society for Assisted Reproductive Technologies Clinical Outcomes Reporting System study. / Holden, Emily C.; Kashani, Banafsheh N.; Morelli, Sara S.; Alderson, Donald; Jindal, Sangita K.; Ohman-Strickland, Pamela A.; McGovern, Peter G.

In: Fertility and Sterility, Vol. 110, No. 1, 01.07.2018, p. 89-94.e2.

Research output: Contribution to journalArticle

Holden, Emily C. ; Kashani, Banafsheh N. ; Morelli, Sara S. ; Alderson, Donald ; Jindal, Sangita K. ; Ohman-Strickland, Pamela A. ; McGovern, Peter G. / Improved outcomes after blastocyst-stage frozen-thawed embryo transfers compared with cleavage stage : a Society for Assisted Reproductive Technologies Clinical Outcomes Reporting System study. In: Fertility and Sterility. 2018 ; Vol. 110, No. 1. pp. 89-94.e2.
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abstract = "Objective: To investigate whether there is a difference in obstetrical and perinatal outcomes in blastocyst frozen-thawed embryo transfers (FETs) compared with cleavage-stage FET. Design: A retrospective cohort study. Setting: Not applicable. Patient(s): Women undergoing autologous FETs at either the blastocyst stage (n = 118,572) or the cleavage stage (n = 117,619) reported to the Society for Assisted Reproductive Technology in the years 2004–2013. Intervention(s): None. Main Outcome Measure(s): Live birth, gestational age, birth weight, miscarriage. Result(s): After controlling for confounders, there were a 49{\%} increased odds of live birth after blastocyst-stage FET compared with cleavage-stage FET (odds ratio [OR] = 1.49; 95{\%} confidence interval [CI], 1.44, 1.54). Additionally, blastocyst FET was associated with a 68{\%} (OR = 1.68; 95{\%} CI, 1.63, 1.74) increased odds of clinical pregnancy and an 7{\%} (OR = 0.93; 95{\%} CI, 0.88, 0.92) decreased odds of miscarriage. There was also a 16{\%} increased odds of preterm delivery (OR = 1.16; 95{\%} CI, 1.06, 1.27) after blastocyst FET but no difference in birth weights. Conclusion(s): In patients undergoing FET, blastocyst-stage transfer is associated with higher live-birth rates when compared with cleavage-stage transfers. Furthermore, perinatal outcomes are similar between the groups.",
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AU - Ohman-Strickland, Pamela A.

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AB - Objective: To investigate whether there is a difference in obstetrical and perinatal outcomes in blastocyst frozen-thawed embryo transfers (FETs) compared with cleavage-stage FET. Design: A retrospective cohort study. Setting: Not applicable. Patient(s): Women undergoing autologous FETs at either the blastocyst stage (n = 118,572) or the cleavage stage (n = 117,619) reported to the Society for Assisted Reproductive Technology in the years 2004–2013. Intervention(s): None. Main Outcome Measure(s): Live birth, gestational age, birth weight, miscarriage. Result(s): After controlling for confounders, there were a 49% increased odds of live birth after blastocyst-stage FET compared with cleavage-stage FET (odds ratio [OR] = 1.49; 95% confidence interval [CI], 1.44, 1.54). Additionally, blastocyst FET was associated with a 68% (OR = 1.68; 95% CI, 1.63, 1.74) increased odds of clinical pregnancy and an 7% (OR = 0.93; 95% CI, 0.88, 0.92) decreased odds of miscarriage. There was also a 16% increased odds of preterm delivery (OR = 1.16; 95% CI, 1.06, 1.27) after blastocyst FET but no difference in birth weights. Conclusion(s): In patients undergoing FET, blastocyst-stage transfer is associated with higher live-birth rates when compared with cleavage-stage transfers. Furthermore, perinatal outcomes are similar between the groups.

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