Improved exercise performance and skeletal muscle strength after simulated altitude exposure: A novel approach for patients with chronic heart failure

Omar Saeed, Vivek Bhatia, Philip Formica, Auris Browne, Thomas K. Aldrich, Jooyoung (Julia) Shin, Simon Maybaum

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Adaptation to altitude leads to beneficial physiologic changes that improve oxygen delivery and utilization by the periphery. Athletes have used simulated altitude enclosures as part of their training regimen to improve exercise performance. We hypothesized that changes due to acclimatization would also be beneficial for patients with heart failure (HF). We report the results of a pilot study of altitude exposure in patients with chronic HF. Methods and Results: Subjects with chronic stable HF, left ventricular ejection fraction (LVEF) ≤35%, on optimal medical therapy were enrolled and underwent simulated altitude exposure for 10 sessions, each 3-4 hours, over a period of 22 days. Starting altitude was 1,500 m and was increased by 300 m with each subsequent session to a maximum altitude of 2,700 m. Peak oxygen consumption, 6-minute walk distance (6MW), skeletal muscle strength, quality of life scores, LVEF, and hematologic parameters were measured at baseline and 48 hours and 4 weeks after the final session. Twelve subjects (median age 52.5 y, ejection fraction 31.7%) successfully completed the protocol without any adverse effects. Peak oxygen consumption significantly improved after altitude sessions from 13.5 ± 1.8 to 14.2 ± 1.9 mL kg -1 min -1 (P =.036) and remained elevated after 4 weeks. There were significant improvements in exercise time, 6MW, skeletal muscle strength, and quality of life scores and a trend toward improvement in LVEF after completion of altitude sessions, which were sustained after 1 month. Conclusions: Simulated altitude exposure up to 2,700 m is safe and well tolerated in patients with chronic stable HF and may have beneficial effects on exercise performance, muscular strength, and quality of life.

Original languageEnglish (US)
Pages (from-to)387-391
Number of pages5
JournalJournal of Cardiac Failure
Volume18
Issue number5
DOIs
StatePublished - May 2012

Fingerprint

Muscle Strength
Skeletal Muscle
Heart Failure
Exercise
Stroke Volume
Quality of Life
Oxygen Consumption
Acclimatization
Athletes
Oxygen

Keywords

  • exercise capacity
  • heart failure
  • Simulated altitude exposure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Improved exercise performance and skeletal muscle strength after simulated altitude exposure : A novel approach for patients with chronic heart failure. / Saeed, Omar; Bhatia, Vivek; Formica, Philip; Browne, Auris; Aldrich, Thomas K.; Shin, Jooyoung (Julia); Maybaum, Simon.

In: Journal of Cardiac Failure, Vol. 18, No. 5, 05.2012, p. 387-391.

Research output: Contribution to journalArticle

@article{ab67a6a87f434ebbb0c8c5071942abcb,
title = "Improved exercise performance and skeletal muscle strength after simulated altitude exposure: A novel approach for patients with chronic heart failure",
abstract = "Background: Adaptation to altitude leads to beneficial physiologic changes that improve oxygen delivery and utilization by the periphery. Athletes have used simulated altitude enclosures as part of their training regimen to improve exercise performance. We hypothesized that changes due to acclimatization would also be beneficial for patients with heart failure (HF). We report the results of a pilot study of altitude exposure in patients with chronic HF. Methods and Results: Subjects with chronic stable HF, left ventricular ejection fraction (LVEF) ≤35{\%}, on optimal medical therapy were enrolled and underwent simulated altitude exposure for 10 sessions, each 3-4 hours, over a period of 22 days. Starting altitude was 1,500 m and was increased by 300 m with each subsequent session to a maximum altitude of 2,700 m. Peak oxygen consumption, 6-minute walk distance (6MW), skeletal muscle strength, quality of life scores, LVEF, and hematologic parameters were measured at baseline and 48 hours and 4 weeks after the final session. Twelve subjects (median age 52.5 y, ejection fraction 31.7{\%}) successfully completed the protocol without any adverse effects. Peak oxygen consumption significantly improved after altitude sessions from 13.5 ± 1.8 to 14.2 ± 1.9 mL kg -1 min -1 (P =.036) and remained elevated after 4 weeks. There were significant improvements in exercise time, 6MW, skeletal muscle strength, and quality of life scores and a trend toward improvement in LVEF after completion of altitude sessions, which were sustained after 1 month. Conclusions: Simulated altitude exposure up to 2,700 m is safe and well tolerated in patients with chronic stable HF and may have beneficial effects on exercise performance, muscular strength, and quality of life.",
keywords = "exercise capacity, heart failure, Simulated altitude exposure",
author = "Omar Saeed and Vivek Bhatia and Philip Formica and Auris Browne and Aldrich, {Thomas K.} and Shin, {Jooyoung (Julia)} and Simon Maybaum",
year = "2012",
month = "5",
doi = "10.1016/j.cardfail.2012.02.003",
language = "English (US)",
volume = "18",
pages = "387--391",
journal = "Journal of Cardiac Failure",
issn = "1071-9164",
publisher = "Churchill Livingstone",
number = "5",

}

TY - JOUR

T1 - Improved exercise performance and skeletal muscle strength after simulated altitude exposure

T2 - A novel approach for patients with chronic heart failure

AU - Saeed, Omar

AU - Bhatia, Vivek

AU - Formica, Philip

AU - Browne, Auris

AU - Aldrich, Thomas K.

AU - Shin, Jooyoung (Julia)

AU - Maybaum, Simon

PY - 2012/5

Y1 - 2012/5

N2 - Background: Adaptation to altitude leads to beneficial physiologic changes that improve oxygen delivery and utilization by the periphery. Athletes have used simulated altitude enclosures as part of their training regimen to improve exercise performance. We hypothesized that changes due to acclimatization would also be beneficial for patients with heart failure (HF). We report the results of a pilot study of altitude exposure in patients with chronic HF. Methods and Results: Subjects with chronic stable HF, left ventricular ejection fraction (LVEF) ≤35%, on optimal medical therapy were enrolled and underwent simulated altitude exposure for 10 sessions, each 3-4 hours, over a period of 22 days. Starting altitude was 1,500 m and was increased by 300 m with each subsequent session to a maximum altitude of 2,700 m. Peak oxygen consumption, 6-minute walk distance (6MW), skeletal muscle strength, quality of life scores, LVEF, and hematologic parameters were measured at baseline and 48 hours and 4 weeks after the final session. Twelve subjects (median age 52.5 y, ejection fraction 31.7%) successfully completed the protocol without any adverse effects. Peak oxygen consumption significantly improved after altitude sessions from 13.5 ± 1.8 to 14.2 ± 1.9 mL kg -1 min -1 (P =.036) and remained elevated after 4 weeks. There were significant improvements in exercise time, 6MW, skeletal muscle strength, and quality of life scores and a trend toward improvement in LVEF after completion of altitude sessions, which were sustained after 1 month. Conclusions: Simulated altitude exposure up to 2,700 m is safe and well tolerated in patients with chronic stable HF and may have beneficial effects on exercise performance, muscular strength, and quality of life.

AB - Background: Adaptation to altitude leads to beneficial physiologic changes that improve oxygen delivery and utilization by the periphery. Athletes have used simulated altitude enclosures as part of their training regimen to improve exercise performance. We hypothesized that changes due to acclimatization would also be beneficial for patients with heart failure (HF). We report the results of a pilot study of altitude exposure in patients with chronic HF. Methods and Results: Subjects with chronic stable HF, left ventricular ejection fraction (LVEF) ≤35%, on optimal medical therapy were enrolled and underwent simulated altitude exposure for 10 sessions, each 3-4 hours, over a period of 22 days. Starting altitude was 1,500 m and was increased by 300 m with each subsequent session to a maximum altitude of 2,700 m. Peak oxygen consumption, 6-minute walk distance (6MW), skeletal muscle strength, quality of life scores, LVEF, and hematologic parameters were measured at baseline and 48 hours and 4 weeks after the final session. Twelve subjects (median age 52.5 y, ejection fraction 31.7%) successfully completed the protocol without any adverse effects. Peak oxygen consumption significantly improved after altitude sessions from 13.5 ± 1.8 to 14.2 ± 1.9 mL kg -1 min -1 (P =.036) and remained elevated after 4 weeks. There were significant improvements in exercise time, 6MW, skeletal muscle strength, and quality of life scores and a trend toward improvement in LVEF after completion of altitude sessions, which were sustained after 1 month. Conclusions: Simulated altitude exposure up to 2,700 m is safe and well tolerated in patients with chronic stable HF and may have beneficial effects on exercise performance, muscular strength, and quality of life.

KW - exercise capacity

KW - heart failure

KW - Simulated altitude exposure

UR - http://www.scopus.com/inward/record.url?scp=84860490803&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860490803&partnerID=8YFLogxK

U2 - 10.1016/j.cardfail.2012.02.003

DO - 10.1016/j.cardfail.2012.02.003

M3 - Article

C2 - 22555269

AN - SCOPUS:84860490803

VL - 18

SP - 387

EP - 391

JO - Journal of Cardiac Failure

JF - Journal of Cardiac Failure

SN - 1071-9164

IS - 5

ER -