Improved anamnestic response among adolescents boosted with a higher dose of the hepatitis B vaccine

Sandra S. Chaves; Justina Groeger; Louisa Helgenberger; Steven B. Auerbach; Stephanie R. Bialek; Dale J. Hu; Jan Drobeniuc

doi:10.1016/j.vaccine.2010.01.059

Improved anamnestic response among adolescents boosted with a higher dose of the hepatitis B vaccine

Sandra S. Chaves, Justina Groeger, Louisa Helgenberger, Steven B. Auerbach, Stephanie R. Bialek, Dale J. Hu, Jan Drobeniuc

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Some hepatitis B vaccine booster studies have suggested waning of vaccine-induced immunity in adolescents vaccinated starting at birth. Those studies, however, used a pediatric formulation of the hepatitis B vaccine as a booster to detect anamnestic response. We compared adolescents boosted with an adult dose of hepatitis B vaccine with those boosted with a pediatric dose. Among adolescents who had lost protective antibody levels against hepatitis B, a higher proportion had an anamnestic response when boosted with the adult dose (60.0% vs. 43.8%). Thus, higher antigen concentrations may be required to elicit an adequate immune memory response. Despite improved anamnestic response, our study still raises concerns about whether children immunized in early infancy will remain protected from hepatitis B as they age into adulthood.

Original language	English (US)
Pages (from-to)	2860-2864
Number of pages	5
Journal	Vaccine
Volume	28
Issue number	16
DOIs	https://doi.org/10.1016/j.vaccine.2010.01.059
State	Published - Apr 1 2010
Externally published	Yes

Keywords

Anamnestic response
Hepatitis B vaccination
Hepatitis B virus
Long term immunity

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.vaccine.2010.01.059

Cite this

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title = "Improved anamnestic response among adolescents boosted with a higher dose of the hepatitis B vaccine",

abstract = "Some hepatitis B vaccine booster studies have suggested waning of vaccine-induced immunity in adolescents vaccinated starting at birth. Those studies, however, used a pediatric formulation of the hepatitis B vaccine as a booster to detect anamnestic response. We compared adolescents boosted with an adult dose of hepatitis B vaccine with those boosted with a pediatric dose. Among adolescents who had lost protective antibody levels against hepatitis B, a higher proportion had an anamnestic response when boosted with the adult dose (60.0% vs. 43.8%). Thus, higher antigen concentrations may be required to elicit an adequate immune memory response. Despite improved anamnestic response, our study still raises concerns about whether children immunized in early infancy will remain protected from hepatitis B as they age into adulthood.",

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note = "Funding Information: We are extremely grateful to all participants and those who contributed to the implementation of this project—the field study team and nurses, in particular Mr Spencer Donre, Mr Hinden Allexander and Ms Kiomy Noket, and CDC Hepatitis Reference Laboratory personnel—Ms Tracy Green-Monthfort and Mrs Ngok-Thao Le. This study could not be done without the valuable support of the Department of Health & Social Affairs, Federated States of Micronesia National Government, Palikir, Pohnpei, FSM. This research was supported in part by an appointment to the Research Participation Program at the Centers for Disease Control and Prevention administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and CDC.",

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Improved anamnestic response among adolescents boosted with a higher dose of the hepatitis B vaccine

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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