TY - JOUR
T1 - Important role of oxidative stress biomarkers in Huntington's disease
AU - Túnez, Isaac
AU - Sánchez-López, Fernando
AU - Agüera, Eduardo
AU - Fernández-Bolaños, Ricardo
AU - Sánchez, Francisco Manuel
AU - Tasset-Cuevas, Inmaculada
PY - 2011/8/11
Y1 - 2011/8/11
N2 - This study examined global oxidative stress (GOS) and antioxidant system and their correlation with disease stage in 19 patients with HD. The results revealed an increase in oxidative stress biomarkers and a reduction in antioxidant systems in HD patients. The effects were more intense in HD1 than in HD2 patients. Additionally, carbonylated proteins and GOS were correlated with disease stage. These findings suggest that oxidative stress plays an important role in the pathogenesis of HD.
AB - This study examined global oxidative stress (GOS) and antioxidant system and their correlation with disease stage in 19 patients with HD. The results revealed an increase in oxidative stress biomarkers and a reduction in antioxidant systems in HD patients. The effects were more intense in HD1 than in HD2 patients. Additionally, carbonylated proteins and GOS were correlated with disease stage. These findings suggest that oxidative stress plays an important role in the pathogenesis of HD.
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U2 - 10.1021/jm200605a
DO - 10.1021/jm200605a
M3 - Article
C2 - 21678912
AN - SCOPUS:79961219601
SN - 0022-2623
VL - 54
SP - 5602
EP - 5606
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
IS - 15
ER -