Important role of oxidative stress biomarkers in Huntington's disease

Isaac Túnez, Fernando Sánchez-López, Eduardo Agüera, Ricardo Fernández-Bolaños, Francisco Manuel Sánchez, Inmaculada Tasset-Cuevas

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

This study examined global oxidative stress (GOS) and antioxidant system and their correlation with disease stage in 19 patients with HD. The results revealed an increase in oxidative stress biomarkers and a reduction in antioxidant systems in HD patients. The effects were more intense in HD1 than in HD2 patients. Additionally, carbonylated proteins and GOS were correlated with disease stage. These findings suggest that oxidative stress plays an important role in the pathogenesis of HD.

Original languageEnglish (US)
Pages (from-to)5602-5606
Number of pages5
JournalJournal of Medicinal Chemistry
Volume54
Issue number15
DOIs
StatePublished - Aug 11 2011
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Cite this

Túnez, I., Sánchez-López, F., Agüera, E., Fernández-Bolaños, R., Sánchez, F. M., & Tasset-Cuevas, I. (2011). Important role of oxidative stress biomarkers in Huntington's disease. Journal of Medicinal Chemistry, 54(15), 5602-5606. https://doi.org/10.1021/jm200605a