Importance of the immune response to the Ro/La particle in the development of congenital heart block and neonatal lupus erythematosus

E. Silverman, M. Mamula, J. A. Hardin, R. Laxer

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

Previous studies have suggested a role for anti-Ro antibodies in the pathogenesis of neonatal lupus erythematosus (NLE). We reexamined the role of the immune response to the Ro/La particle in the development of NLE using newer and more definitive assay techniques. All 15 infants with congenital heart block and NLE had both anti-Ro and anti-La antibodies. Of 8 patients with cutaneous NLE alone, 2 had anti-Ro antibodies alone while the remaining 6 had both anti-Ro and anti-La antibodies. One woman gave birth to 2 children; one had both Ro and La antibodies and developed congenital heart block, the other had only anti-Ro and anti-U1RNP antibodies and was clinically normal. Our study demonstrates that the presence of anti-Ro and anti-La antibodies define the immune response that is associated with the development of congenital heart block of NLE.

Original languageEnglish (US)
Pages (from-to)120-124
Number of pages5
JournalJournal of Rheumatology
Volume18
Issue number1
StatePublished - Jan 1 1991

Keywords

  • Anti-La antibodies
  • Anti-Ro antibodies
  • Congenital heart block
  • Neonatal lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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