Abstract
This article describes the implantation techniques of two new stentless mitral bioprosthesis and their early echocardiographic performance in 12 acute sheep model. The first stentless mitral bioprosthesis (stentless bileaflet valve [SBV]) was designed as a bileaflet valve with sewing ring to suture down to the native mitral annulus. The other one (SBV with chordae) has two chordae-like structures to be attached to the head of the native papillary muscles. Valvar performance and cardiac function were evaluated by epicardial echocardiography at postimplant (Rest) and during dobutamine (DOB) stimulation. Postimplant echocardiography revealed normal leaflet opening with a large orifice area and unrestricted leaflets motion. In both valves, leaflet closure showed no systolic anterior motion, prolapse, or tethering. Mitral regurgitation grade 2 or higher was not detected in any of the experiments. Transvalvar pressure gradients at Rest and DOB were 2.3 ± 1.6 mm Hg and 2.5 ± 2.2 mm Hg in SBV and 1.8 ± 1.1 mm Hg and 2.3 ± 1.2 mm Hg in SBV with chordae, respectively. Both stentless bioprosthesis showed reliable valve performance and preserved cardiac function in the acute phase. Further chronic study is needed to evaluate the reliability of implantation procedures, valvar performance, and biocompatibility.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 497-503 |
| Number of pages | 7 |
| Journal | ASAIO Journal |
| Volume | 56 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 2010 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biophysics
- Biomaterials
- Bioengineering
- Biomedical Engineering
- Medicine(all)
Cite this
Implantation technique and early echocardiographic performance of newly designed stentless mitral bioprosthesis. / Navia, Jose L.; Brozzi, Nicolas; Doi, Kazuyoshi; Garcia, Mario J.; Al-Ruzzeh, Sharif; Atik, Fernando A.; Fukamachi, Kiyotaka; Xu, Xiao Fung; Kamohara, Keiji; Gonzalez-Stawinski, Gonzalo V.; Lytle, Bruce.
In: ASAIO Journal, Vol. 56, No. 6, 11.2010, p. 497-503.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Implantation technique and early echocardiographic performance of newly designed stentless mitral bioprosthesis
AU - Navia, Jose L.
AU - Brozzi, Nicolas
AU - Doi, Kazuyoshi
AU - Garcia, Mario J.
AU - Al-Ruzzeh, Sharif
AU - Atik, Fernando A.
AU - Fukamachi, Kiyotaka
AU - Xu, Xiao Fung
AU - Kamohara, Keiji
AU - Gonzalez-Stawinski, Gonzalo V.
AU - Lytle, Bruce
PY - 2010/11
Y1 - 2010/11
N2 - This article describes the implantation techniques of two new stentless mitral bioprosthesis and their early echocardiographic performance in 12 acute sheep model. The first stentless mitral bioprosthesis (stentless bileaflet valve [SBV]) was designed as a bileaflet valve with sewing ring to suture down to the native mitral annulus. The other one (SBV with chordae) has two chordae-like structures to be attached to the head of the native papillary muscles. Valvar performance and cardiac function were evaluated by epicardial echocardiography at postimplant (Rest) and during dobutamine (DOB) stimulation. Postimplant echocardiography revealed normal leaflet opening with a large orifice area and unrestricted leaflets motion. In both valves, leaflet closure showed no systolic anterior motion, prolapse, or tethering. Mitral regurgitation grade 2 or higher was not detected in any of the experiments. Transvalvar pressure gradients at Rest and DOB were 2.3 ± 1.6 mm Hg and 2.5 ± 2.2 mm Hg in SBV and 1.8 ± 1.1 mm Hg and 2.3 ± 1.2 mm Hg in SBV with chordae, respectively. Both stentless bioprosthesis showed reliable valve performance and preserved cardiac function in the acute phase. Further chronic study is needed to evaluate the reliability of implantation procedures, valvar performance, and biocompatibility.
AB - This article describes the implantation techniques of two new stentless mitral bioprosthesis and their early echocardiographic performance in 12 acute sheep model. The first stentless mitral bioprosthesis (stentless bileaflet valve [SBV]) was designed as a bileaflet valve with sewing ring to suture down to the native mitral annulus. The other one (SBV with chordae) has two chordae-like structures to be attached to the head of the native papillary muscles. Valvar performance and cardiac function were evaluated by epicardial echocardiography at postimplant (Rest) and during dobutamine (DOB) stimulation. Postimplant echocardiography revealed normal leaflet opening with a large orifice area and unrestricted leaflets motion. In both valves, leaflet closure showed no systolic anterior motion, prolapse, or tethering. Mitral regurgitation grade 2 or higher was not detected in any of the experiments. Transvalvar pressure gradients at Rest and DOB were 2.3 ± 1.6 mm Hg and 2.5 ± 2.2 mm Hg in SBV and 1.8 ± 1.1 mm Hg and 2.3 ± 1.2 mm Hg in SBV with chordae, respectively. Both stentless bioprosthesis showed reliable valve performance and preserved cardiac function in the acute phase. Further chronic study is needed to evaluate the reliability of implantation procedures, valvar performance, and biocompatibility.
UR - http://www.scopus.com/inward/record.url?scp=78349311461&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78349311461&partnerID=8YFLogxK
U2 - 10.1097/MAT.0b013e3181f67e0c
DO - 10.1097/MAT.0b013e3181f67e0c
M3 - Article
C2 - 20944501
AN - SCOPUS:78349311461
VL - 56
SP - 497
EP - 503
JO - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JF - ASAIO journal (American Society for Artificial Internal Organs : 1992)
SN - 1058-2916
IS - 6
ER -