TY - JOUR
T1 - Impaired autonomic function in normotensive obese children
AU - Latchman, Peter L.
AU - Mathur, Madhu
AU - Bartels, Matthew N.
AU - Axtell, Robert S.
AU - De Meersman, Ronald E.
N1 - Funding Information:
Acknowledgments This study is supported by research funds granted by the VIDDA foundation.
PY - 2011/10
Y1 - 2011/10
N2 - Purpose To evaluate baroreflex sensitivity and autonomic control in a cohort of normotensive obese (OB) children. Method A cross-sectional investigation, in which, baroreflex sensitivity and autonomic control were evaluated using transfer function and power spectral density analysis (PSDA) of the electrocardiogram and beat-to-beat blood pressures in normotensive OB children and normal weight normotensive controls. All methods used were noninvasive and data were captured while seated and at rest. Results The OB and control subjects non-obese (NO) were of similar age (OB 9.1 ± 1.9 years vs.NO9.2 ± 1.4 years). The OB group was classified as having a BMI greater than the 95th percentile adjusted for age and gender, and a NO group with a BMI at or less than the 95th percentile (BMI percentile OB. 97.5 ± 1.3 vs. NO 58.5 ± 24.1). Both groups had similar normotensive blood pressures. T tests revealed that baroreflex sensitivity and HFRR were significantly reduced in the OB 9.2 ± 2.7 vs. 15.2 ± 4.7 (ms/mmHg) and 6.7 ± 1.1 vs. 8.2 ± 1.1 ms 2, respectively, while LF SBP and LF/HF ratio were significantly increased in the OB 11.9 ± 5.6 vs. 8.2 ± 4.7 mmHg 2 and 1.2 ± 0.7 vs. 0.54 ± 0.3, respectively. Conclusions Normotensive OB children exhibited significantly reduced baroreflex sensitivity, parasympathetic control as well as increased sympathetic control when compared with healthy, NO controls. Findings in this investigation raise the awareness that autonomic dysfunction is present in young OB normotensive children.
AB - Purpose To evaluate baroreflex sensitivity and autonomic control in a cohort of normotensive obese (OB) children. Method A cross-sectional investigation, in which, baroreflex sensitivity and autonomic control were evaluated using transfer function and power spectral density analysis (PSDA) of the electrocardiogram and beat-to-beat blood pressures in normotensive OB children and normal weight normotensive controls. All methods used were noninvasive and data were captured while seated and at rest. Results The OB and control subjects non-obese (NO) were of similar age (OB 9.1 ± 1.9 years vs.NO9.2 ± 1.4 years). The OB group was classified as having a BMI greater than the 95th percentile adjusted for age and gender, and a NO group with a BMI at or less than the 95th percentile (BMI percentile OB. 97.5 ± 1.3 vs. NO 58.5 ± 24.1). Both groups had similar normotensive blood pressures. T tests revealed that baroreflex sensitivity and HFRR were significantly reduced in the OB 9.2 ± 2.7 vs. 15.2 ± 4.7 (ms/mmHg) and 6.7 ± 1.1 vs. 8.2 ± 1.1 ms 2, respectively, while LF SBP and LF/HF ratio were significantly increased in the OB 11.9 ± 5.6 vs. 8.2 ± 4.7 mmHg 2 and 1.2 ± 0.7 vs. 0.54 ± 0.3, respectively. Conclusions Normotensive OB children exhibited significantly reduced baroreflex sensitivity, parasympathetic control as well as increased sympathetic control when compared with healthy, NO controls. Findings in this investigation raise the awareness that autonomic dysfunction is present in young OB normotensive children.
KW - Autonomic modulation
KW - Baroreflex sensitivity
KW - Normotensive
KW - Obese children
UR - http://www.scopus.com/inward/record.url?scp=83255164201&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=83255164201&partnerID=8YFLogxK
U2 - 10.1007/s10286-011-0116-8
DO - 10.1007/s10286-011-0116-8
M3 - Article
C2 - 21318460
AN - SCOPUS:83255164201
SN - 0959-9851
VL - 21
SP - 319
EP - 323
JO - Clinical Autonomic Research
JF - Clinical Autonomic Research
IS - 5
ER -