Impact on rats from acute intratracheal inhalation exposures to WTC dusts

Mitchell D. Cohen, Colette Prophete, Lori Horton, Maureen Sisco, Sung Hyun Park, Hyun Wook Lee, Judith Zelikoff, Lung Chi Chen

Research output: Contribution to journalArticle

Abstract

Background: Studies have revealed the increased incidence of health disorders in First Responders (FR) who were at Ground Zero over the initial 72 hr after the World Trade Center (WTC) collapses. Previous studies in rats exposed to WTC dusts using exposure scenarios that mimicked FR mouthbreathing showed exposure led to altered expression of genes whose products could be involved in lung ailments. Nevertheless, it was uncertain if repeated exposures (as occurred in earliest days post-disaster) might have given rise to long-term changes in the lungs/other organs, in white blood cell (WBC) profiles, and/or systemic expression of select (mostly immune-related) proteins. Methods: To examine this, rats were exposed on 2 consecutive days (2 hr/d, intratracheal inhalation) to WTC dusts and then examined over a 1-yr period thereafter. At select times post-exposure, organ (lung, heart, liver, kidney, spleen) weights, WBC profiles, and blood levels of a variety of proteins were evaluated. Results: The study showed that over the 1-yr period, there were nominal effects on organ weights (absolute, index) as a result of the dust exposures. There were significant changes (relative to in naïve rats) in WBC profiles, with exposed rats having increased monocyte-macrophage and decreased lymphocyte percentages. The study also found that dust exposure led to significant systemic increases in many proteins, including MCP-1, RANTES, MMP-9, RAGE, and Galectin-3. Conclusions: These results provide further support for our longstanding hypothesis that the WTC dusts could potentially have acted as direct inducers of many of the health effects that have been seen in the exposed FR.

Original languageEnglish (US)
Pages (from-to)218-230
Number of pages13
JournalInhalation Toxicology
Volume32
Issue number5
DOIs
StatePublished - Apr 15 2020
Externally publishedYes

Keywords

  • dust
  • heart
  • kidney
  • liver
  • lung
  • serum
  • spleen
  • World Trade Center
  • WTC

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Fingerprint Dive into the research topics of 'Impact on rats from acute intratracheal inhalation exposures to WTC dusts'. Together they form a unique fingerprint.

  • Cite this

    Cohen, M. D., Prophete, C., Horton, L., Sisco, M., Park, S. H., Lee, H. W., Zelikoff, J., & Chen, L. C. (2020). Impact on rats from acute intratracheal inhalation exposures to WTC dusts. Inhalation Toxicology, 32(5), 218-230. https://doi.org/10.1080/08958378.2020.1768322