Impact of uncontrolled hypertension on atrial fibrillation ablation outcome

Francesco Santoro, Luigi Di Biase, Chintan Trivedi, John David Burkhardt, Alessandro Paoletti Perini, Javier Sanchez, Rodney Horton, Prasant Mohanty, Sanghamitra Mohanty, Rong Bai, Pasquale Santangeli, Dhanunjay Lakkireddy, Madhu Reddy, Claude Samy Elayi, Richard Hongo, Salwa Beheiry, Steven Hao, Robert A. Schweikert, Juan Viles-Gonzalez, Gaetano FassiniMichela Casella, Antonio Dello Russo, Claudio Tondo, Andrea Natale

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objectives The goal of this study was to evaluate the impact of hypertension on the outcome of atrial fibrillation (AF) ablation. Background Hypertension is a well-known independent risk factor for incident AF. Methods A total of 531 consecutive patients undergoing AF ablation were enrolled in this study and divided into 3 groups: patients with uncontrolled hypertension despite medical treatment (group I, n = 160), patients with controlled hypertension (group II, n = 192), and patients without hypertension (group III, n = 179). Pulmonary vein (PV) antrum and posterior wall isolation was always performed, and non-PV triggers were identified during isoproterenol infusion. All patients underwent extensive follow-up. Results Three groups differed in terms of left atrial (LA) size, non-PV triggers, and moderate/severe LA scar. Non-PV triggers were present in 94 (58.8%), 64 (33.3%), and 50 (27.9%) patients in groups I, II, and III, respectively (p <0.001). After 19 ± 7.7 months of follow-up, 65 (40.6%), 54 (28.1%), and 46 (25.7%) patients in groups I, II, and III had recurrences (log-rank test, p = 0.003). Among patients in group I who underwent additional non-PV trigger ablation, freedom from AF/atrial tachycardia was 69.8%, which was similar to groups II and III procedural success (log-rank p = 0.7). After adjusting for confounders, uncontrolled hypertension (group I) (hazard ratio [HR]: 1.52, p = 0.045), non-PV triggers (HR: 1.85, p <0.001), and nonparoxysmal AF (HR: 1.64, p = 0.002) demonstrated significant association with arrhythmia recurrence. Conclusions Controlled hypertension does not affect the AF ablation outcome when compared with patients without hypertension. By contrast, uncontrolled hypertension confers higher AF recurrence risk and requires more extensive ablation.

Original languageEnglish (US)
Pages (from-to)164-173
Number of pages10
JournalJACC: Clinical Electrophysiology
Volume1
Issue number3
DOIs
StatePublished - Jun 1 2015

Fingerprint

Atrial Fibrillation
Hypertension
Veins
Recurrence
Pulmonary Veins
Isoproterenol
Tachycardia
Cicatrix
Cardiac Arrhythmias

Keywords

  • atrial fibrillation
  • catheter ablation
  • hypertension
  • non-PV triggers
  • pulmonary vein isolation
  • uncontrolled hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Santoro, F., Di Biase, L., Trivedi, C., Burkhardt, J. D., Paoletti Perini, A., Sanchez, J., ... Natale, A. (2015). Impact of uncontrolled hypertension on atrial fibrillation ablation outcome. JACC: Clinical Electrophysiology, 1(3), 164-173. https://doi.org/10.1016/j.jacep.2015.04.002

Impact of uncontrolled hypertension on atrial fibrillation ablation outcome. / Santoro, Francesco; Di Biase, Luigi; Trivedi, Chintan; Burkhardt, John David; Paoletti Perini, Alessandro; Sanchez, Javier; Horton, Rodney; Mohanty, Prasant; Mohanty, Sanghamitra; Bai, Rong; Santangeli, Pasquale; Lakkireddy, Dhanunjay; Reddy, Madhu; Elayi, Claude Samy; Hongo, Richard; Beheiry, Salwa; Hao, Steven; Schweikert, Robert A.; Viles-Gonzalez, Juan; Fassini, Gaetano; Casella, Michela; Dello Russo, Antonio; Tondo, Claudio; Natale, Andrea.

In: JACC: Clinical Electrophysiology, Vol. 1, No. 3, 01.06.2015, p. 164-173.

Research output: Contribution to journalArticle

Santoro, F, Di Biase, L, Trivedi, C, Burkhardt, JD, Paoletti Perini, A, Sanchez, J, Horton, R, Mohanty, P, Mohanty, S, Bai, R, Santangeli, P, Lakkireddy, D, Reddy, M, Elayi, CS, Hongo, R, Beheiry, S, Hao, S, Schweikert, RA, Viles-Gonzalez, J, Fassini, G, Casella, M, Dello Russo, A, Tondo, C & Natale, A 2015, 'Impact of uncontrolled hypertension on atrial fibrillation ablation outcome', JACC: Clinical Electrophysiology, vol. 1, no. 3, pp. 164-173. https://doi.org/10.1016/j.jacep.2015.04.002
Santoro, Francesco ; Di Biase, Luigi ; Trivedi, Chintan ; Burkhardt, John David ; Paoletti Perini, Alessandro ; Sanchez, Javier ; Horton, Rodney ; Mohanty, Prasant ; Mohanty, Sanghamitra ; Bai, Rong ; Santangeli, Pasquale ; Lakkireddy, Dhanunjay ; Reddy, Madhu ; Elayi, Claude Samy ; Hongo, Richard ; Beheiry, Salwa ; Hao, Steven ; Schweikert, Robert A. ; Viles-Gonzalez, Juan ; Fassini, Gaetano ; Casella, Michela ; Dello Russo, Antonio ; Tondo, Claudio ; Natale, Andrea. / Impact of uncontrolled hypertension on atrial fibrillation ablation outcome. In: JACC: Clinical Electrophysiology. 2015 ; Vol. 1, No. 3. pp. 164-173.
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abstract = "Objectives The goal of this study was to evaluate the impact of hypertension on the outcome of atrial fibrillation (AF) ablation. Background Hypertension is a well-known independent risk factor for incident AF. Methods A total of 531 consecutive patients undergoing AF ablation were enrolled in this study and divided into 3 groups: patients with uncontrolled hypertension despite medical treatment (group I, n = 160), patients with controlled hypertension (group II, n = 192), and patients without hypertension (group III, n = 179). Pulmonary vein (PV) antrum and posterior wall isolation was always performed, and non-PV triggers were identified during isoproterenol infusion. All patients underwent extensive follow-up. Results Three groups differed in terms of left atrial (LA) size, non-PV triggers, and moderate/severe LA scar. Non-PV triggers were present in 94 (58.8{\%}), 64 (33.3{\%}), and 50 (27.9{\%}) patients in groups I, II, and III, respectively (p <0.001). After 19 ± 7.7 months of follow-up, 65 (40.6{\%}), 54 (28.1{\%}), and 46 (25.7{\%}) patients in groups I, II, and III had recurrences (log-rank test, p = 0.003). Among patients in group I who underwent additional non-PV trigger ablation, freedom from AF/atrial tachycardia was 69.8{\%}, which was similar to groups II and III procedural success (log-rank p = 0.7). After adjusting for confounders, uncontrolled hypertension (group I) (hazard ratio [HR]: 1.52, p = 0.045), non-PV triggers (HR: 1.85, p <0.001), and nonparoxysmal AF (HR: 1.64, p = 0.002) demonstrated significant association with arrhythmia recurrence. Conclusions Controlled hypertension does not affect the AF ablation outcome when compared with patients without hypertension. By contrast, uncontrolled hypertension confers higher AF recurrence risk and requires more extensive ablation.",
keywords = "atrial fibrillation, catheter ablation, hypertension, non-PV triggers, pulmonary vein isolation, uncontrolled hypertension",
author = "Francesco Santoro and {Di Biase}, Luigi and Chintan Trivedi and Burkhardt, {John David} and {Paoletti Perini}, Alessandro and Javier Sanchez and Rodney Horton and Prasant Mohanty and Sanghamitra Mohanty and Rong Bai and Pasquale Santangeli and Dhanunjay Lakkireddy and Madhu Reddy and Elayi, {Claude Samy} and Richard Hongo and Salwa Beheiry and Steven Hao and Schweikert, {Robert A.} and Juan Viles-Gonzalez and Gaetano Fassini and Michela Casella and {Dello Russo}, Antonio and Claudio Tondo and Andrea Natale",
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T1 - Impact of uncontrolled hypertension on atrial fibrillation ablation outcome

AU - Santoro, Francesco

AU - Di Biase, Luigi

AU - Trivedi, Chintan

AU - Burkhardt, John David

AU - Paoletti Perini, Alessandro

AU - Sanchez, Javier

AU - Horton, Rodney

AU - Mohanty, Prasant

AU - Mohanty, Sanghamitra

AU - Bai, Rong

AU - Santangeli, Pasquale

AU - Lakkireddy, Dhanunjay

AU - Reddy, Madhu

AU - Elayi, Claude Samy

AU - Hongo, Richard

AU - Beheiry, Salwa

AU - Hao, Steven

AU - Schweikert, Robert A.

AU - Viles-Gonzalez, Juan

AU - Fassini, Gaetano

AU - Casella, Michela

AU - Dello Russo, Antonio

AU - Tondo, Claudio

AU - Natale, Andrea

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Objectives The goal of this study was to evaluate the impact of hypertension on the outcome of atrial fibrillation (AF) ablation. Background Hypertension is a well-known independent risk factor for incident AF. Methods A total of 531 consecutive patients undergoing AF ablation were enrolled in this study and divided into 3 groups: patients with uncontrolled hypertension despite medical treatment (group I, n = 160), patients with controlled hypertension (group II, n = 192), and patients without hypertension (group III, n = 179). Pulmonary vein (PV) antrum and posterior wall isolation was always performed, and non-PV triggers were identified during isoproterenol infusion. All patients underwent extensive follow-up. Results Three groups differed in terms of left atrial (LA) size, non-PV triggers, and moderate/severe LA scar. Non-PV triggers were present in 94 (58.8%), 64 (33.3%), and 50 (27.9%) patients in groups I, II, and III, respectively (p <0.001). After 19 ± 7.7 months of follow-up, 65 (40.6%), 54 (28.1%), and 46 (25.7%) patients in groups I, II, and III had recurrences (log-rank test, p = 0.003). Among patients in group I who underwent additional non-PV trigger ablation, freedom from AF/atrial tachycardia was 69.8%, which was similar to groups II and III procedural success (log-rank p = 0.7). After adjusting for confounders, uncontrolled hypertension (group I) (hazard ratio [HR]: 1.52, p = 0.045), non-PV triggers (HR: 1.85, p <0.001), and nonparoxysmal AF (HR: 1.64, p = 0.002) demonstrated significant association with arrhythmia recurrence. Conclusions Controlled hypertension does not affect the AF ablation outcome when compared with patients without hypertension. By contrast, uncontrolled hypertension confers higher AF recurrence risk and requires more extensive ablation.

AB - Objectives The goal of this study was to evaluate the impact of hypertension on the outcome of atrial fibrillation (AF) ablation. Background Hypertension is a well-known independent risk factor for incident AF. Methods A total of 531 consecutive patients undergoing AF ablation were enrolled in this study and divided into 3 groups: patients with uncontrolled hypertension despite medical treatment (group I, n = 160), patients with controlled hypertension (group II, n = 192), and patients without hypertension (group III, n = 179). Pulmonary vein (PV) antrum and posterior wall isolation was always performed, and non-PV triggers were identified during isoproterenol infusion. All patients underwent extensive follow-up. Results Three groups differed in terms of left atrial (LA) size, non-PV triggers, and moderate/severe LA scar. Non-PV triggers were present in 94 (58.8%), 64 (33.3%), and 50 (27.9%) patients in groups I, II, and III, respectively (p <0.001). After 19 ± 7.7 months of follow-up, 65 (40.6%), 54 (28.1%), and 46 (25.7%) patients in groups I, II, and III had recurrences (log-rank test, p = 0.003). Among patients in group I who underwent additional non-PV trigger ablation, freedom from AF/atrial tachycardia was 69.8%, which was similar to groups II and III procedural success (log-rank p = 0.7). After adjusting for confounders, uncontrolled hypertension (group I) (hazard ratio [HR]: 1.52, p = 0.045), non-PV triggers (HR: 1.85, p <0.001), and nonparoxysmal AF (HR: 1.64, p = 0.002) demonstrated significant association with arrhythmia recurrence. Conclusions Controlled hypertension does not affect the AF ablation outcome when compared with patients without hypertension. By contrast, uncontrolled hypertension confers higher AF recurrence risk and requires more extensive ablation.

KW - atrial fibrillation

KW - catheter ablation

KW - hypertension

KW - non-PV triggers

KW - pulmonary vein isolation

KW - uncontrolled hypertension

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