TY - JOUR
T1 - Impact of polychlorinated biphenyls (PCBs) on the immune function of fish
T2 - Age as a variable in determining adverse outcome
AU - Duffy, J. E.
AU - Carlson, E.
AU - Li, Y.
AU - Prophete, C.
AU - Zelikoff, J. T.
N1 - Funding Information:
This work was supported by U.S. Army contract DAMD 17-99-9011. We thank Dr. C.D. Rice for providing monoclonal anti-trout CYP1A1 antibody C10-7.
PY - 2002/9
Y1 - 2002/9
N2 - Polychlorinated biphenyls (PCBs) are a major contaminant of global extent in water resources and aquatic biota. Due to its high lipid solubility, PCBs fail to be degraded and, therefore, continue to bioaccumulate throughout the environment and food chain. To determine the impact of PCBs on the immune system of aged and juvenile Japanese medaka (Oryzias latipes), fish were injected with the coplanar PCB congener 126 and examined after 3 and 14 days. PCB 126 produced oxidative stress in both age groups of fish 14 days post-injection; however, juvenile medaka appeared more susceptible than aged fish. Humoral immunity, as determined by antibody forming cell (AFC) numbers, was significantly depressed for up to 14 days post-injection in both age groups. These results demonstrate the sensitivity of the fish immune response for predicting PCB-induced immunotoxicity and identify age as a variable in determining adverse outcome.
AB - Polychlorinated biphenyls (PCBs) are a major contaminant of global extent in water resources and aquatic biota. Due to its high lipid solubility, PCBs fail to be degraded and, therefore, continue to bioaccumulate throughout the environment and food chain. To determine the impact of PCBs on the immune system of aged and juvenile Japanese medaka (Oryzias latipes), fish were injected with the coplanar PCB congener 126 and examined after 3 and 14 days. PCB 126 produced oxidative stress in both age groups of fish 14 days post-injection; however, juvenile medaka appeared more susceptible than aged fish. Humoral immunity, as determined by antibody forming cell (AFC) numbers, was significantly depressed for up to 14 days post-injection in both age groups. These results demonstrate the sensitivity of the fish immune response for predicting PCB-induced immunotoxicity and identify age as a variable in determining adverse outcome.
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U2 - 10.1016/S0141-1136(02)00176-9
DO - 10.1016/S0141-1136(02)00176-9
M3 - Article
C2 - 12408617
AN - SCOPUS:0036752968
SN - 0141-1136
VL - 54
SP - 559
EP - 563
JO - Marine Environmental Research
JF - Marine Environmental Research
IS - 3-5
ER -