Impact of polychlorinated biphenyls (PCBs) on the immune function of fish

Age as a variable in determining adverse outcome

J. E. Duffy, E. Carlson, Y. Li, Colette M. Prophete, J. T. Zelikoff

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Polychlorinated biphenyls (PCBs) are a major contaminant of global extent in water resources and aquatic biota. Due to its high lipid solubility, PCBs fail to be degraded and, therefore, continue to bioaccumulate throughout the environment and food chain. To determine the impact of PCBs on the immune system of aged and juvenile Japanese medaka (Oryzias latipes), fish were injected with the coplanar PCB congener 126 and examined after 3 and 14 days. PCB 126 produced oxidative stress in both age groups of fish 14 days post-injection; however, juvenile medaka appeared more susceptible than aged fish. Humoral immunity, as determined by antibody forming cell (AFC) numbers, was significantly depressed for up to 14 days post-injection in both age groups. These results demonstrate the sensitivity of the fish immune response for predicting PCB-induced immunotoxicity and identify age as a variable in determining adverse outcome.

Original languageEnglish (US)
Pages (from-to)559-563
Number of pages5
JournalMarine Environmental Research
Volume54
Issue number3-5
DOIs
StatePublished - Sep 2002
Externally publishedYes

Fingerprint

polychlorinated biphenyls
Polychlorinated biphenyls
Fish
PCB
fish
Oryzias latipes
immunotoxicity
injection
Oxidative stress
Immune system
immune system
immunity
immune response
Water resources
food chain
Antibodies
humoral immunity
water resources
Lipids
antibody

ASJC Scopus subject areas

  • Aquatic Science
  • Oceanography
  • Environmental Science(all)

Cite this

Impact of polychlorinated biphenyls (PCBs) on the immune function of fish : Age as a variable in determining adverse outcome. / Duffy, J. E.; Carlson, E.; Li, Y.; Prophete, Colette M.; Zelikoff, J. T.

In: Marine Environmental Research, Vol. 54, No. 3-5, 09.2002, p. 559-563.

Research output: Contribution to journalArticle

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