Impact of periprocedural colchicine on postprocedural management in patients undergoing a left atrial appendage ligation using LARIAT

Sampath Gunda, Madhu Reddy, Jayant Nath, Hosakote Nagaraj, Moustapha Atoui, Abdi Rasekh, Christopher R. Ellis, Nitish Badhwar, Randall J. Lee, Luigi Di Biase, Moussa Mansour, Jeremy N. Ruskin, Andrea Natale, Matthew Earnest, Dhanunjaya R. Lakkireddy

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Periprocedural Colchicine for Epicardial Access Procedures Introduction Left atrial appendage (LAA) can be effectively and safely excluded using a novel percutaneous LARIAT ligation system. However, due to pericardial catheter manipulation and LAA ligation and subsequent necrosis, postprocedural course is complicated by pericarditis. We intended to evaluate the preprocedural use of colchicine on the incidence of postprocedural pericardial complications. Methods and Results In this multicenter observational study, we included all consecutive patients who underwent LARIAT procedure at the participating centers. Many patients received periprocedural colchicine at the discretion of the physician. We compared the postprocedural outcomes of patients who received prophylactic periprocedural colchicine (colchicine group) with those who did not receive colchicine (standard group). A total of 344 consecutive patients, 243 in the "colchicine group" and 101 in the "standard group," were included. The mean age, median CHADS2VASc score, and HASBLED scores were 70 ± 11 years, 3 ± 1.7, and 3 ± 1.1, respectively. There were no significant differences in major baseline characteristics between the two groups. Severe pericarditis was significantly lower in the "colchicine group" compared to the "standard group" (10 [4%] vs. 16 [16%] P

Original languageEnglish (US)
Pages (from-to)60-64
Number of pages5
JournalJournal of Cardiovascular Electrophysiology
Volume27
Issue number1
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Fingerprint

Atrial Appendage
Colchicine
Ligation
Pericarditis
Multicenter Studies
Observational Studies
Necrosis
Catheters
Physicians
Incidence

Keywords

  • atrial fibrillation
  • colchicine
  • LARIAT procedure
  • left atrial appendage
  • pericarditis
  • stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Impact of periprocedural colchicine on postprocedural management in patients undergoing a left atrial appendage ligation using LARIAT. / Gunda, Sampath; Reddy, Madhu; Nath, Jayant; Nagaraj, Hosakote; Atoui, Moustapha; Rasekh, Abdi; Ellis, Christopher R.; Badhwar, Nitish; Lee, Randall J.; Di Biase, Luigi; Mansour, Moussa; Ruskin, Jeremy N.; Natale, Andrea; Earnest, Matthew; Lakkireddy, Dhanunjaya R.

In: Journal of Cardiovascular Electrophysiology, Vol. 27, No. 1, 01.01.2016, p. 60-64.

Research output: Contribution to journalArticle

Gunda, S, Reddy, M, Nath, J, Nagaraj, H, Atoui, M, Rasekh, A, Ellis, CR, Badhwar, N, Lee, RJ, Di Biase, L, Mansour, M, Ruskin, JN, Natale, A, Earnest, M & Lakkireddy, DR 2016, 'Impact of periprocedural colchicine on postprocedural management in patients undergoing a left atrial appendage ligation using LARIAT', Journal of Cardiovascular Electrophysiology, vol. 27, no. 1, pp. 60-64. https://doi.org/10.1111/jce.12869
Gunda, Sampath ; Reddy, Madhu ; Nath, Jayant ; Nagaraj, Hosakote ; Atoui, Moustapha ; Rasekh, Abdi ; Ellis, Christopher R. ; Badhwar, Nitish ; Lee, Randall J. ; Di Biase, Luigi ; Mansour, Moussa ; Ruskin, Jeremy N. ; Natale, Andrea ; Earnest, Matthew ; Lakkireddy, Dhanunjaya R. / Impact of periprocedural colchicine on postprocedural management in patients undergoing a left atrial appendage ligation using LARIAT. In: Journal of Cardiovascular Electrophysiology. 2016 ; Vol. 27, No. 1. pp. 60-64.
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abstract = "Periprocedural Colchicine for Epicardial Access Procedures Introduction Left atrial appendage (LAA) can be effectively and safely excluded using a novel percutaneous LARIAT ligation system. However, due to pericardial catheter manipulation and LAA ligation and subsequent necrosis, postprocedural course is complicated by pericarditis. We intended to evaluate the preprocedural use of colchicine on the incidence of postprocedural pericardial complications. Methods and Results In this multicenter observational study, we included all consecutive patients who underwent LARIAT procedure at the participating centers. Many patients received periprocedural colchicine at the discretion of the physician. We compared the postprocedural outcomes of patients who received prophylactic periprocedural colchicine (colchicine group) with those who did not receive colchicine (standard group). A total of 344 consecutive patients, 243 in the {"}colchicine group{"} and 101 in the {"}standard group,{"} were included. The mean age, median CHADS2VASc score, and HASBLED scores were 70 ± 11 years, 3 ± 1.7, and 3 ± 1.1, respectively. There were no significant differences in major baseline characteristics between the two groups. Severe pericarditis was significantly lower in the {"}colchicine group{"} compared to the {"}standard group{"} (10 [4{\%}] vs. 16 [16{\%}] P",
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AU - Mansour, Moussa

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