Impact of nodal staging for small bowel carcinoid

More is better!

Thuy Tran, Heidi Reich, Anna Leung, Edward Wolin, Farin Amersi, Danielle M. Hari

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Current guidelines for small bowel carcinoid (SBC) do not specify the extent lymph node (LN) staging required. Our aim was to determine whether analyzing more LNs in patients who undergo surgical resection for SBC correlated with improved survival. The Surveillance, Epidemiology, and End Results (SEER) database was queried to identify patients undergoing surgical resection for histologically confirmed SBC from 1988- 2009. The number of LNs examined was categorized into 0, 1 to 6, 7 to 11 and 12+ nodes. Patient demographics and tumor characteristics were assessed by Logrank and Cox regression analysis. The median number of LNs examined for all 2796 patients was 4.00 (mean 6.83). For all stages of jejunal and ileal tumors examined, increased nodal sampling was associated with significantly improved survival (p < 0.001). On regression analysis, older age, non-white race, larger tumor size, higher T-stage and number of LNs examined were predictive of worse survival. For jejunal and ileal SBC, adequate lymphadenectomy, consisting of 12 lymph nodes, correlates with significantly improved survival. Presently, no guideline exists for SBC LN staging, but it is critical to ensure adequate surgical staging in patients who undergo resection for jejunal and ileal SBC.

Original languageEnglish (US)
Pages (from-to)65-70
Number of pages6
JournalWorld Journal of Endocrine Surgery
Volume5
Issue number3
DOIs
StatePublished - 2013
Externally publishedYes

Fingerprint

Carcinoid Tumor
Survival
Lymph Nodes
Regression Analysis
Guidelines
Neoplasms
Lymph Node Excision
Epidemiology
Demography
Databases

Keywords

  • Lymph nodes
  • Small bowel carcinoid
  • Survival

ASJC Scopus subject areas

  • Surgery
  • Endocrinology, Diabetes and Metabolism
  • Radiology Nuclear Medicine and imaging

Cite this

Impact of nodal staging for small bowel carcinoid : More is better! / Tran, Thuy; Reich, Heidi; Leung, Anna; Wolin, Edward; Amersi, Farin; Hari, Danielle M.

In: World Journal of Endocrine Surgery, Vol. 5, No. 3, 2013, p. 65-70.

Research output: Contribution to journalArticle

Tran, T, Reich, H, Leung, A, Wolin, E, Amersi, F & Hari, DM 2013, 'Impact of nodal staging for small bowel carcinoid: More is better!', World Journal of Endocrine Surgery, vol. 5, no. 3, pp. 65-70. https://doi.org/10.5005/jp.journals-10002-1131
Tran, Thuy ; Reich, Heidi ; Leung, Anna ; Wolin, Edward ; Amersi, Farin ; Hari, Danielle M. / Impact of nodal staging for small bowel carcinoid : More is better!. In: World Journal of Endocrine Surgery. 2013 ; Vol. 5, No. 3. pp. 65-70.
@article{3a342f50c73b40f09af5d72bac9b82df,
title = "Impact of nodal staging for small bowel carcinoid: More is better!",
abstract = "Current guidelines for small bowel carcinoid (SBC) do not specify the extent lymph node (LN) staging required. Our aim was to determine whether analyzing more LNs in patients who undergo surgical resection for SBC correlated with improved survival. The Surveillance, Epidemiology, and End Results (SEER) database was queried to identify patients undergoing surgical resection for histologically confirmed SBC from 1988- 2009. The number of LNs examined was categorized into 0, 1 to 6, 7 to 11 and 12+ nodes. Patient demographics and tumor characteristics were assessed by Logrank and Cox regression analysis. The median number of LNs examined for all 2796 patients was 4.00 (mean 6.83). For all stages of jejunal and ileal tumors examined, increased nodal sampling was associated with significantly improved survival (p < 0.001). On regression analysis, older age, non-white race, larger tumor size, higher T-stage and number of LNs examined were predictive of worse survival. For jejunal and ileal SBC, adequate lymphadenectomy, consisting of 12 lymph nodes, correlates with significantly improved survival. Presently, no guideline exists for SBC LN staging, but it is critical to ensure adequate surgical staging in patients who undergo resection for jejunal and ileal SBC.",
keywords = "Lymph nodes, Small bowel carcinoid, Survival",
author = "Thuy Tran and Heidi Reich and Anna Leung and Edward Wolin and Farin Amersi and Hari, {Danielle M.}",
year = "2013",
doi = "10.5005/jp.journals-10002-1131",
language = "English (US)",
volume = "5",
pages = "65--70",
journal = "World Journal of Endocrine Surgery",
issn = "0975-5039",
publisher = "Jaypee Brothers Medical Publishers (P) Ltd",
number = "3",

}

TY - JOUR

T1 - Impact of nodal staging for small bowel carcinoid

T2 - More is better!

AU - Tran, Thuy

AU - Reich, Heidi

AU - Leung, Anna

AU - Wolin, Edward

AU - Amersi, Farin

AU - Hari, Danielle M.

PY - 2013

Y1 - 2013

N2 - Current guidelines for small bowel carcinoid (SBC) do not specify the extent lymph node (LN) staging required. Our aim was to determine whether analyzing more LNs in patients who undergo surgical resection for SBC correlated with improved survival. The Surveillance, Epidemiology, and End Results (SEER) database was queried to identify patients undergoing surgical resection for histologically confirmed SBC from 1988- 2009. The number of LNs examined was categorized into 0, 1 to 6, 7 to 11 and 12+ nodes. Patient demographics and tumor characteristics were assessed by Logrank and Cox regression analysis. The median number of LNs examined for all 2796 patients was 4.00 (mean 6.83). For all stages of jejunal and ileal tumors examined, increased nodal sampling was associated with significantly improved survival (p < 0.001). On regression analysis, older age, non-white race, larger tumor size, higher T-stage and number of LNs examined were predictive of worse survival. For jejunal and ileal SBC, adequate lymphadenectomy, consisting of 12 lymph nodes, correlates with significantly improved survival. Presently, no guideline exists for SBC LN staging, but it is critical to ensure adequate surgical staging in patients who undergo resection for jejunal and ileal SBC.

AB - Current guidelines for small bowel carcinoid (SBC) do not specify the extent lymph node (LN) staging required. Our aim was to determine whether analyzing more LNs in patients who undergo surgical resection for SBC correlated with improved survival. The Surveillance, Epidemiology, and End Results (SEER) database was queried to identify patients undergoing surgical resection for histologically confirmed SBC from 1988- 2009. The number of LNs examined was categorized into 0, 1 to 6, 7 to 11 and 12+ nodes. Patient demographics and tumor characteristics were assessed by Logrank and Cox regression analysis. The median number of LNs examined for all 2796 patients was 4.00 (mean 6.83). For all stages of jejunal and ileal tumors examined, increased nodal sampling was associated with significantly improved survival (p < 0.001). On regression analysis, older age, non-white race, larger tumor size, higher T-stage and number of LNs examined were predictive of worse survival. For jejunal and ileal SBC, adequate lymphadenectomy, consisting of 12 lymph nodes, correlates with significantly improved survival. Presently, no guideline exists for SBC LN staging, but it is critical to ensure adequate surgical staging in patients who undergo resection for jejunal and ileal SBC.

KW - Lymph nodes

KW - Small bowel carcinoid

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=84902166725&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902166725&partnerID=8YFLogxK

U2 - 10.5005/jp.journals-10002-1131

DO - 10.5005/jp.journals-10002-1131

M3 - Article

VL - 5

SP - 65

EP - 70

JO - World Journal of Endocrine Surgery

JF - World Journal of Endocrine Surgery

SN - 0975-5039

IS - 3

ER -