Impact of myocardial structure and function postinfarction on diastolic strain measurements

Implications for assessment of myocardial viability

Tae Ho Park, Sherif F. Nagueh, Dirar S. Khoury, Helen A. Kopelen, Spyridon Akrivakis, Kamal Nasser, Guofeng Ren, Nikolaos G. Frangogiannis

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

We sought to assess the role of regional diastolic function by Doppler echocardiography in predicting myocardial viability. Sixteen dogs underwent left anterior descending coronary artery (n = 8) or circumflex (n = 8) occlusion. All animals were imaged at baseline and 1-8 wk postinfarction (post-MI). In 10 dogs, invasive hemodynamic monitoring with a conductance catheter placed in the left ventricle (LV) was performed at the above time points. Dobutamine was infused at 1-8 wk post-MI to determine LV contractile reserve. Histomorphological analysis was performed to determine the presence of viable myocardium and changes in interstitial matrix. Post-MI, diastolic strain rate measurements (in radial and longitudinal planes) decreased significantly in the distribution of the diseased artery (P < 0.01) and on multiple regression analysis were determined by time constant of LV relaxation, end-diastolic pressure, regional stiffness, and the ratio of cellular infiltration to collagen deposition in the interstitial matrix. Among several indexes, diastolic strain rate during dobutamine infusion readily identified segments with >20% transmural infarction and related best to the extent of interstitial fibrosis (r = -0.86, P < 0.01). In an animal model of healing canine infarcts, diastolic strain rate by Doppler echocardiography appears to be a promising novel index of myocardial viability.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume290
Issue number2
DOIs
StatePublished - Feb 2006
Externally publishedYes

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Doppler Echocardiography
Heart Ventricles
Dogs
Dobutamine
Infarction
Canidae
Coronary Vessels
Myocardium
Fibrosis
Catheters
Animal Models
Arteries
Hemodynamics

Keywords

  • Coronary
  • Diastole
  • Infarction

ASJC Scopus subject areas

  • Physiology

Cite this

Impact of myocardial structure and function postinfarction on diastolic strain measurements : Implications for assessment of myocardial viability. / Park, Tae Ho; Nagueh, Sherif F.; Khoury, Dirar S.; Kopelen, Helen A.; Akrivakis, Spyridon; Nasser, Kamal; Ren, Guofeng; Frangogiannis, Nikolaos G.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 290, No. 2, 02.2006.

Research output: Contribution to journalArticle

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