@article{fb87af944d05467f92086f264dbf60f7,
title = "Impact of methadone treatment on cardiac repolarization and conduction in opioid users",
abstract = "We prospectively assessed the effect of oral methadone on the corrected QT interval (QTc) among 160 patients free of structural heart disease and measured serum methadone concentrations and simultaneous QTc intervals in a subset of 44 participants. Mean ± SD QTc increased by 12.4 ± 23 ms (p <0.001) at 6 months, by 10.7 ± 30 ms (p <0.001) at 12 months, and the QTc change from baseline to 12 months correlated with the trough (r = 0.37, p = 0.008) and peak (r = 0.32, p = 0.03) serum methadone concentrations.",
author = "Martell, {Bridget A.} and Arnsten, {Julia H.} and Krantz, {Mori J.} and Gourevitch, {Marc N.}",
note = "Funding Information: Dr. Martell was supported by a VA Connecticut Healthcare Cooperative Studies Program Career Development award CRCD# 733A, West Haven, Connecticut. Dr. Arnsten was supported by a Robert Wood Johnson Generalist Physician Faculty Scholar Award, Princeton, New Jersey and by Grant R25 DA14551 from the National Institutes of Health, Bethesda, Maryland. The Division of Substance Abuse at the Albert Einstein College of Medicine is funded in part by Contract C-002464 from the New York State Office of Alcoholism and Substance Abuse Services, New York, New York. ",
year = "2005",
month = apr,
day = "1",
doi = "10.1016/j.amjcard.2004.11.055",
language = "English (US)",
volume = "95",
pages = "915--918",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "7",
}