Impact of methadone treatment on cardiac repolarization and conduction in opioid users

Bridget A. Martell, Julia H. Arnsten, Mori J. Krantz, Marc N. Gourevitch

Research output: Contribution to journalArticle

131 Scopus citations


We prospectively assessed the effect of oral methadone on the corrected QT interval (QTc) among 160 patients free of structural heart disease and measured serum methadone concentrations and simultaneous QTc intervals in a subset of 44 participants. Mean ± SD QTc increased by 12.4 ± 23 ms (p <0.001) at 6 months, by 10.7 ± 30 ms (p <0.001) at 12 months, and the QTc change from baseline to 12 months correlated with the trough (r = 0.37, p = 0.008) and peak (r = 0.32, p = 0.03) serum methadone concentrations.

Original languageEnglish (US)
Pages (from-to)915-918
Number of pages4
JournalAmerican Journal of Cardiology
Issue number7
StatePublished - Apr 1 2005
Externally publishedYes


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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