Impact of intraprocedural thrombotic events on short- and long-term outcomes following percutaneous coronary intervention. Evidence from a meta-analysis

Ramez Nairooz, Dmitriy N. Feldman, Yogita Rochlani, Wilbert S. Aronow, Partha Sardar, Debabrata Mukherjee, Srihari S. Naidu, Pranav Patel

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Data regarding the effects of intraprocedural thrombotic events (IPTE) are scarce. Hence we aim to perform a meta-analysis to examine the outcomes of IPTE compared to non-IPTE during PCI. Methods: We performed a literature search of all published full-length articles of studies that reported data on patients with IPTE compared with non-IPTE during PCI. We calculated odd ratios via random effects model. Results: A total of 26,697 patients, of which 1572 patients had IPTE, were included in this analysis. In-hospital, IPTE was associated with higher mortality (odds ratio (OR) 5.36, 95% confidence interval (CI) [2.31, 12.41]; p < 0.0001), myocardial infarction (MI) and major bleeding compared to non-IPTE. At 30 days, IPTE was also associated with higher mortality (OR 4.57, 95% CI [2.43, 8.60]; p < 0.0001), MI, repeat revascularization, stent thrombosis and major bleeding compared to non-IPTE group. IPTE was also associated with higher long-term mortality (OR 2.19, 95% CI [1.35, 3.53]; p = 0.001). Among IPTE patients, intraprocedural stent thrombosis was associated with greater odds of MI compared to both no reflow and distal embolization events. Conclusion: IPTE during PCI is associated with more adverse ischemic events, including mortality, during the index hospitalization, at 30 days and long-term.

Original languageEnglish (US)
Pages (from-to)469-476
Number of pages8
JournalInternational Journal of Cardiology
Volume202
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Keywords

  • Distal embolization
  • Intraprocedural thrombotic events
  • No reflow
  • PCI

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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