Impact of elution impurities on DOTA and NOTA labeling with two commercial 68Ge/68Ga generators

Alejandro Amor-Coarasa, Monika Gruca, Sophie Hurez, Seza A. Gulec, Anthony McGoron, John W. Babich

Research output: Contribution to journalArticle

Abstract

Different amounts of commercial p-SCN-Bn-DOTA and p-SCN-Bn-NOTA (Macrocyclics, USA) were labeled with 68Ga from IGG-100 purified and unpurified elutions and ITG unpurified elution at different incubation times and temperature. Significant differences in labeling yield were found. Using the ITG generator’s direct elution up to 560 GBq/µmol molar activity can be obtained, while a maximum of 185 GBq/µmol can be obtained with direct elution of the IGG-100 generator. Purification of the elution of the IGG-100 generator increases the labeling yields significantly. Both generators perform per manufacturer specifications and are routinely used for the preparation of 68Ga imaging agents in the clinic.

Original languageEnglish (US)
Pages (from-to)1485-1490
Number of pages6
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume317
Issue number3
DOIs
StatePublished - Sep 1 2018
Externally publishedYes

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Labeling
Impurities
Temperature
Purification
Specifications
Imaging techniques
1,4,7-triazacyclononane-N,N',N''-triacetic acid

Keywords

  • Ga generator
  • Eckert and Ziegler
  • Generator comparison
  • IGG-100 generator
  • ITG generator

ASJC Scopus subject areas

  • Analytical Chemistry
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Pollution
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Impact of elution impurities on DOTA and NOTA labeling with two commercial 68Ge/68Ga generators. / Amor-Coarasa, Alejandro; Gruca, Monika; Hurez, Sophie; Gulec, Seza A.; McGoron, Anthony; Babich, John W.

In: Journal of Radioanalytical and Nuclear Chemistry, Vol. 317, No. 3, 01.09.2018, p. 1485-1490.

Research output: Contribution to journalArticle

Amor-Coarasa, Alejandro ; Gruca, Monika ; Hurez, Sophie ; Gulec, Seza A. ; McGoron, Anthony ; Babich, John W. / Impact of elution impurities on DOTA and NOTA labeling with two commercial 68Ge/68Ga generators. In: Journal of Radioanalytical and Nuclear Chemistry. 2018 ; Vol. 317, No. 3. pp. 1485-1490.
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AU - McGoron, Anthony

AU - Babich, John W.

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