Impact of elution impurities on DOTA and NOTA labeling with two commercial 68Ge/68Ga generators

Alejandro Amor-Coarasa; Monika Gruca; Sophie Hurez; Seza A. Gulec; Anthony McGoron; John W. Babich

doi:10.1007/s10967-018-6011-1

Impact of elution impurities on DOTA and NOTA labeling with two commercial ⁶⁸Ge/⁶⁸Ga generators

Alejandro Amor-Coarasa, Monika Gruca, Sophie Hurez, Seza A. Gulec, Anthony McGoron, John W. Babich

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Different amounts of commercial p-SCN-Bn-DOTA and p-SCN-Bn-NOTA (Macrocyclics, USA) were labeled with ⁶⁸Ga from IGG-100 purified and unpurified elutions and ITG unpurified elution at different incubation times and temperature. Significant differences in labeling yield were found. Using the ITG generator’s direct elution up to 560 GBq/µmol molar activity can be obtained, while a maximum of 185 GBq/µmol can be obtained with direct elution of the IGG-100 generator. Purification of the elution of the IGG-100 generator increases the labeling yields significantly. Both generators perform per manufacturer specifications and are routinely used for the preparation of ⁶⁸Ga imaging agents in the clinic.

Original language	English (US)
Pages (from-to)	1485-1490
Number of pages	6
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	317
Issue number	3
DOIs	https://doi.org/10.1007/s10967-018-6011-1
State	Published - Sep 1 2018
Externally published	Yes

Keywords

Eckert and Ziegler
Ga generator
Generator comparison
IGG-100 generator
ITG generator

ASJC Scopus subject areas

Analytical Chemistry
Nuclear Energy and Engineering
Radiology Nuclear Medicine and imaging
Pollution
Spectroscopy
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s10967-018-6011-1

Cite this

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title = "Impact of elution impurities on DOTA and NOTA labeling with two commercial 68Ge/68Ga generators",

abstract = "Different amounts of commercial p-SCN-Bn-DOTA and p-SCN-Bn-NOTA (Macrocyclics, USA) were labeled with 68Ga from IGG-100 purified and unpurified elutions and ITG unpurified elution at different incubation times and temperature. Significant differences in labeling yield were found. Using the ITG generator{\textquoteright}s direct elution up to 560 GBq/µmol molar activity can be obtained, while a maximum of 185 GBq/µmol can be obtained with direct elution of the IGG-100 generator. Purification of the elution of the IGG-100 generator increases the labeling yields significantly. Both generators perform per manufacturer specifications and are routinely used for the preparation of 68Ga imaging agents in the clinic.",

keywords = "Eckert and Ziegler, Ga generator, Generator comparison, IGG-100 generator, ITG generator",

author = "Alejandro Amor-Coarasa and Monika Gruca and Sophie Hurez and Gulec, {Seza A.} and Anthony McGoron and Babich, {John W.}",

note = "Publisher Copyright: {\textcopyright} 2018, Akad{\'e}miai Kiad{\'o}, Budapest, Hungary.",

year = "2018",

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doi = "10.1007/s10967-018-6011-1",

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T1 - Impact of elution impurities on DOTA and NOTA labeling with two commercial 68Ge/68Ga generators

AU - Amor-Coarasa, Alejandro

AU - Gruca, Monika

AU - Hurez, Sophie

AU - Gulec, Seza A.

AU - McGoron, Anthony

AU - Babich, John W.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Different amounts of commercial p-SCN-Bn-DOTA and p-SCN-Bn-NOTA (Macrocyclics, USA) were labeled with 68Ga from IGG-100 purified and unpurified elutions and ITG unpurified elution at different incubation times and temperature. Significant differences in labeling yield were found. Using the ITG generator’s direct elution up to 560 GBq/µmol molar activity can be obtained, while a maximum of 185 GBq/µmol can be obtained with direct elution of the IGG-100 generator. Purification of the elution of the IGG-100 generator increases the labeling yields significantly. Both generators perform per manufacturer specifications and are routinely used for the preparation of 68Ga imaging agents in the clinic.

AB - Different amounts of commercial p-SCN-Bn-DOTA and p-SCN-Bn-NOTA (Macrocyclics, USA) were labeled with 68Ga from IGG-100 purified and unpurified elutions and ITG unpurified elution at different incubation times and temperature. Significant differences in labeling yield were found. Using the ITG generator’s direct elution up to 560 GBq/µmol molar activity can be obtained, while a maximum of 185 GBq/µmol can be obtained with direct elution of the IGG-100 generator. Purification of the elution of the IGG-100 generator increases the labeling yields significantly. Both generators perform per manufacturer specifications and are routinely used for the preparation of 68Ga imaging agents in the clinic.

KW - Eckert and Ziegler

KW - Ga generator

KW - Generator comparison

KW - IGG-100 generator

KW - ITG generator

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