Impact of Diabetes Mellitus on Adverse Outcomes After Meningioma Surgery

Karandeep S. Randhawa, Chris B. Choi, Aakash D. Shah, Aksha Parray, Christina H. Fang, James K. Liu, Soly Baredes, Jean Anderson Eloy

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: We sought to investigate the association between diabetes mellitus and incidence of adverse outcomes in patients who underwent meningioma surgery. Methods: The 2012–2014 National Inpatient Sample database was used. Prolonged length of stay was indicated by values greater than the 90th percentile of the sample. The Fisher exact test and analysis of variance were used to compare demographics, hospital characteristics, comorbidity, and complications among race cohorts. Logistic regression was used to analyze the independent effect of diabetes on adverse outcomes. Results: After selecting for patients with primary diagnosis of meningioma who underwent a resection procedure, 7745 individuals were identified and divided into diabetic (n = 1518) and nondiabetic (n = 6227) cohorts. Demographics, hospital characteristics, and comorbidities were significantly different among the 2 cohorts. Average length of stay was longer in diabetic patients (8.15 vs. 6.04 days, P < 0.001), and total charges were higher in diabetic patients ($139,462.66 vs. $123,250.71, P < 0.001). Multivariate regression indicated diabetic patients have higher odds of experiencing a complication (odds ratio [OR] 1.442, 95% confidence interval [CI] 1.255–1.656, P < 0.001) and in-hospital mortality (OR 1.672, 95% CI 1.034–2.705, P = 0.036) after meningioma surgery. Analysis of individual postoperative complications revealed that diabetic patients experienced increased odds of pulmonary (OR 1.501, 95% CI 1.209–1.864, P < 0.001), neurologic (OR 1.690, 95% CI 1.383–2.065, P < 0.001), and urinary/renal complications (OR 2.618, 95% CI 1.933–3.545, P < 0.001). In addition, diabetic patients were more likely to have a prolonged length of stay (OR 1.694, 95% CI 1.389–2.065, P < 0.001). Conclusions: Diabetes is an important factor associated with complications after meningioma surgery. Preventative measures must be taken to optimize postoperative outcomes in these patients.

Original languageEnglish (US)
Pages (from-to)e429-e435
JournalWorld Neurosurgery
Volume152
DOIs
StatePublished - Aug 2021
Externally publishedYes

Keywords

  • Complications
  • Diabetes mellitus
  • Meningioma
  • Outcomes

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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