Abstract
Problem: Effects of HIV infection on ovarian function and aging are unclear. Method of study: Anti-Müllerian Hormone (AMH) levels were analyzed in 2621 HIV-infected and 941 uninfected participants using left-censored longitudinal models. Results: Age-adjusted AMH levels were 16% lower in women with undetectable viraemia and 26% lower in detectable viraemia, relative to uninfected women. Current CD4 count associated with higher AMH in both HIV-infected and HIV-uninfected women. After controlling for current and nadir CD4, AMH was ~15% higher in HIV-infected relative to uninfected women, regardless of HIV viraemia. Gravidity, amenorrhea, and nadir total lymphocyte counts associated with higher AMH; hormonal contraceptive use and past weight loss associated with lower AMH. Conclusions: CD4 + lymphocyte counts were associated with AMH in both HIV-infected and uninfected women. After adjustment for CD4 counts and age, HIV infection was associated with higher AMH. CD4 T cells and cellular activation may influence ovarian granulosa cell function.
Original language | English (US) |
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Pages (from-to) | 273-284 |
Number of pages | 12 |
Journal | American Journal of Reproductive Immunology |
Volume | 73 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1 2015 |
Keywords
- Anti-Müllerian hormone
- CD4 lymphocytes
- HIV
- Menopause
- Ovarian follicle
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Reproductive Medicine
- Obstetrics and Gynecology