Impact of CD4+ Lymphocytes and HIV Infection on Anti-Müllerian Hormone Levels in a Large Cohort of HIV-infected and HIV-uninfected Women

Rebecca Scherzer, Peter Bacchetti, Geralyn Messerlian, Johanna Goderre, Pauline M. Maki, David B. Seifer, Kathryn Anastos, Roksana Karim, Ruth M. Greenblatt

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Problem: Effects of HIV infection on ovarian function and aging are unclear. Method of study: Anti-Müllerian Hormone (AMH) levels were analyzed in 2621 HIV-infected and 941 uninfected participants using left-censored longitudinal models. Results: Age-adjusted AMH levels were 16% lower in women with undetectable viraemia and 26% lower in detectable viraemia, relative to uninfected women. Current CD4 count associated with higher AMH in both HIV-infected and HIV-uninfected women. After controlling for current and nadir CD4, AMH was ~15% higher in HIV-infected relative to uninfected women, regardless of HIV viraemia. Gravidity, amenorrhea, and nadir total lymphocyte counts associated with higher AMH; hormonal contraceptive use and past weight loss associated with lower AMH. Conclusions: CD4 + lymphocyte counts were associated with AMH in both HIV-infected and uninfected women. After adjustment for CD4 counts and age, HIV infection was associated with higher AMH. CD4 T cells and cellular activation may influence ovarian granulosa cell function.

Original languageEnglish (US)
Pages (from-to)273-284
Number of pages12
JournalAmerican Journal of Reproductive Immunology
Volume73
Issue number3
DOIs
StatePublished - Mar 1 2015

Fingerprint

HIV Infections
HIV
Hormones
Lymphocytes
Viremia
CD4 Lymphocyte Count
Gravidity
Granulosa Cells
Amenorrhea
Lymphocyte Count
Contraceptive Agents
Weight Loss
T-Lymphocytes

Keywords

  • Anti-Müllerian hormone
  • CD4 lymphocytes
  • HIV
  • Menopause
  • Ovarian follicle

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Impact of CD4+ Lymphocytes and HIV Infection on Anti-Müllerian Hormone Levels in a Large Cohort of HIV-infected and HIV-uninfected Women. / Scherzer, Rebecca; Bacchetti, Peter; Messerlian, Geralyn; Goderre, Johanna; Maki, Pauline M.; Seifer, David B.; Anastos, Kathryn; Karim, Roksana; Greenblatt, Ruth M.

In: American Journal of Reproductive Immunology, Vol. 73, No. 3, 01.03.2015, p. 273-284.

Research output: Contribution to journalArticle

Scherzer, Rebecca ; Bacchetti, Peter ; Messerlian, Geralyn ; Goderre, Johanna ; Maki, Pauline M. ; Seifer, David B. ; Anastos, Kathryn ; Karim, Roksana ; Greenblatt, Ruth M. / Impact of CD4+ Lymphocytes and HIV Infection on Anti-Müllerian Hormone Levels in a Large Cohort of HIV-infected and HIV-uninfected Women. In: American Journal of Reproductive Immunology. 2015 ; Vol. 73, No. 3. pp. 273-284.
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