Immunotherapy: Incorporation in the evolving paradigm of renal cancer management and future prospects

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Significant progress has been made in the management of renal cell carcinoma (RCC) during the last few decades. In early stage, localized disease, surgical resection remains the modality of choice, with no therapeutic interventions as options for post-operative therapy other than simple observation and clinical surveillance. However, treatment options in the advanced or metastatic setting are increasing at a dizzying pace, initially with cytokine therapy, then with the increased availability of targeted therapy including novel small-molecule inhibitors of receptor tyrosine kinases and monoclonal antibodies targeting novel proteins, establishing them as the current standard of care. Even more recently, immunotherapy has seen tremendous development in the form of immune checkpoint inhibition and vaccines. Overall, these interventions have gradually changed the landscape of cancer management in general, and metastatic renal cell carcinoma (mRCC) in particular. This is exemplified by the recent United States Food and Drug Administration (USFDA) approval of nivolumab for patients with mRCC after failure of TKI therapy. In this review, we present a brief overview of the current management of mRCC, primarily the clear cell subtype (ccRCC), and discuss the major clinical trials and data on the immunotherapy in advanced or mRCC.

Original languageEnglish (US)
Pages (from-to)17313-17327
Number of pages15
JournalOncotarget
Volume8
Issue number10
DOIs
StatePublished - 2017

Keywords

  • Checkpoint Inhibition
  • Cytokines
  • Immunotherapy
  • Renal cell carcinoma
  • Vaccines

ASJC Scopus subject areas

  • Oncology

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