Immunology of psoriasis

Michelle A. Lowes, Mayte Suárez-Fariñas, James G. Krueger

Research output: Contribution to journalArticle

491 Citations (Scopus)

Abstract

The skin is the front line of defense against insult and injury and contains many epidermal and immune elements that comprise the skin-Associated lymphoid tissue (SALT). The reaction of these components to injury allows an effective cutaneous response to restore homeostasis. Psoriasis vulgaris is the best-understood and most accessible human disease that is mediated by T cells and dendritic cells. Inflammatory myeloid dendritic cells release IL-23 and IL-12 to activate IL-17-producing T cells, Th1 cells, and Th22 cells to produce abundant psoriatic cytokines IL-17, IFN-γ, TNF, and IL-22. These cytokines mediate effects on keratinocytes to amplify psoriatic inflammation. Therapeutic studies with anticytokine antibodies have shown the importance of the key cytokines IL-23, TNF, and IL-17 in this process. We discuss the genetic background of psoriasis and its relationship to immune function, specifically genetic mutations, key PSORS loci, single nucleotide polymorphisms, and the skin transcriptome. The association between comorbidities and psoriasis is reviewed by correlating the skin transcriptome and serum proteins. Psoriasis-related cytokine-response pathways are considered in the context of the transcriptome of different mouse models. This approach offers a model for other inflammatory skin and autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)227-255
Number of pages29
JournalAnnual Review of Immunology
Volume32
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Allergy and Immunology
Psoriasis
Interleukin-17
Skin
Transcriptome
Cytokines
Interleukin-23
Dendritic Cells
T-Lymphocytes
Th1 Cells
Wounds and Injuries
Lymphoid Tissue
Myeloid Cells
Interleukin-12
Keratinocytes
Skin Diseases
Autoimmune Diseases
Single Nucleotide Polymorphism
Comorbidity
Blood Proteins

Keywords

  • DCs
  • Dendritic cells
  • Healthy skin
  • Keratinocyte
  • Molecular studies
  • Mouse models
  • Skin-Associated lymphoid tissue
  • T cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Lowes, M. A., Suárez-Fariñas, M., & Krueger, J. G. (2014). Immunology of psoriasis. Annual Review of Immunology, 32, 227-255. https://doi.org/10.1146/annurev-immunol-032713-120225

Immunology of psoriasis. / Lowes, Michelle A.; Suárez-Fariñas, Mayte; Krueger, James G.

In: Annual Review of Immunology, Vol. 32, 2014, p. 227-255.

Research output: Contribution to journalArticle

Lowes, MA, Suárez-Fariñas, M & Krueger, JG 2014, 'Immunology of psoriasis', Annual Review of Immunology, vol. 32, pp. 227-255. https://doi.org/10.1146/annurev-immunol-032713-120225
Lowes, Michelle A. ; Suárez-Fariñas, Mayte ; Krueger, James G. / Immunology of psoriasis. In: Annual Review of Immunology. 2014 ; Vol. 32. pp. 227-255.
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