TY - JOUR
T1 - Immunology of COVID-19
T2 - Current State of the Science
AU - The Sinai Immunology Review Project
AU - Vabret, Nicolas
AU - Britton, Graham J.
AU - Gruber, Conor
AU - Hegde, Samarth
AU - Kim, Joel
AU - Kuksin, Maria
AU - Levantovsky, Rachel
AU - Malle, Louise
AU - Moreira, Alvaro
AU - Park, Matthew D.
AU - Pia, Luisanna
AU - Risson, Emma
AU - Saffern, Miriam
AU - Salomé, Bérengère
AU - Esai Selvan, Myvizhi
AU - Spindler, Matthew P.
AU - Tan, Jessica
AU - van der Heide, Verena
AU - Gregory, Jill K.
AU - Alexandropoulos, Konstantina
AU - Bhardwaj, Nina
AU - Brown, Brian D.
AU - Greenbaum, Benjamin
AU - Gümüş, Zeynep H.
AU - Homann, Dirk
AU - Horowitz, Amir
AU - Kamphorst, Alice O.
AU - Curotto de Lafaille, Maria A.
AU - Mehandru, Saurabh
AU - Merad, Miriam
AU - Samstein, Robert M.
AU - Agrawal, Manasi
AU - Aleynick, Mark
AU - Belabed, Meriem
AU - Brown, Matthew
AU - Casanova-Acebes, Maria
AU - Catalan, Jovani
AU - Centa, Monica
AU - Charap, Andrew
AU - Chan, Andrew
AU - Chen, Steven T.
AU - Chung, Jonathan
AU - Bozkus, Cansu Cimen
AU - Cody, Evan
AU - Cossarini, Francesca
AU - Dalla, Erica
AU - Fernandez, Nicolas
AU - Grout, John
AU - Martinez-Delgado, Gustavo
AU - Aguirre-Ghiso, Julio
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/6/16
Y1 - 2020/6/16
N2 - The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an unprecedented effort from the scientific community to understand the biological underpinning of COVID19 pathophysiology. In this Review, we summarize the current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death. We also discuss the rationale and clinical outcome of current therapeutic strategies as well as prospective clinical trials to prevent or treat SARS-CoV-2 infection.
AB - The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an unprecedented effort from the scientific community to understand the biological underpinning of COVID19 pathophysiology. In this Review, we summarize the current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death. We also discuss the rationale and clinical outcome of current therapeutic strategies as well as prospective clinical trials to prevent or treat SARS-CoV-2 infection.
UR - http://www.scopus.com/inward/record.url?scp=85085607706&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85085607706&partnerID=8YFLogxK
U2 - 10.1016/j.immuni.2020.05.002
DO - 10.1016/j.immuni.2020.05.002
M3 - Review article
C2 - 32505227
AN - SCOPUS:85085607706
SN - 1074-7613
VL - 52
SP - 910
EP - 941
JO - Immunity
JF - Immunity
IS - 6
ER -
