Immunologic responses in the gastrointestinal tract of the guinea pig. I. Characterization of Peyer's patch cells

D. M. Levin, D. L. Rosenstreich, H. Y. Reynolds

Research output: Contribution to journalArticle

18 Scopus citations


Guinea pig Peyer's patches contain lymphocytes which demonstrate B cell markers in that they are immunoglobulin bearing and form erythrocyte antibody complement complex rosettes. These Peyer's patches also have lymphocytes with a T cell marker; that is, they are killed by heterologous anti T cell serum. In addition, tissue cltures of the cell population as a whole were greatly stimulated by phytohemaglutinin and concanavalin A, properties ordinarily associated with T cell; the cells were minimally stimulated by endotoxin, a property suggesting the presence of B cells. These data showing both B and T cells further support a secondary lymphoid role for the Peyer's patch in the adult guinea pig.

Original languageEnglish (US)
Pages (from-to)980-983
Number of pages4
JournalJournal of Immunology
Issue number3
Publication statusPublished - Dec 1 1973
Externally publishedYes


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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