Immunohistochemical visualization of afferent nerve terminals in human globus pallidus and its alteration in neostriatal neurodegenerative disorders

S. Goto, A. Hirano, R. R. Rojas-Corona

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The afferent nerve terminal in the human globus pallidus, which receives the projection nerve fibers from both the striatum and the subthalamic nucleus, were clearly visualized immunohistochemically using antibodies to calcineurin, synaptophysin, Met-enkephalin (MEnk) and substance P (SP). In normal control case, MEnk and SP-like immunoreactivities were densely localized in the external and internal pallidal segments, respectively, whereas calcineurin and synaptophysin were distributed throughout the globus pallidus. Calcineurin, synaptophysin, MEnk and SP-like immunoreactive peroxidase products decorated most of the long radiating dendrites and the cell bodies of the pallidal neurons. In the cases with Huntington's disease (HD) and striatonigral degeneration (SND), marked loss of calcineurin, MEnk and SP-like immunoreactivities was seen in the globus pallidus corresponding to areas of striatal neurodegeneration, whereas synaptophysin immunoreactivity remained in areas which revealed almost complete loss of calcineurin, MEnk and SP-like immunoreactivities. Calcineurin, MEnk and SP, which show difference in their localization patterns, may provide reliable markers for the striatal efferent nerve terminals, and synaptophysin for the entire pallidal afferent nerve terminals. This report demonstrates the distribution patterns of these neurochemical molecules in the globus pallidus with HD and SND.

Original languageEnglish (US)
Pages (from-to)543-550
Number of pages8
JournalActa Neuropathologica
Volume78
Issue number5
DOIs
StatePublished - Sep 1989

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Methionine Enkephalin
Globus Pallidus
Calcineurin
Substance P
Synaptophysin
Neurodegenerative Diseases
Striatonigral Degeneration
Corpus Striatum
Huntington Disease
Subthalamic Nucleus
Dendrites
Nerve Fibers
Peroxidase
Neurons
Antibodies

Keywords

  • Calcineurin
  • Globus pallidus
  • Immunohistochemistry
  • Neuropeptides
  • Synaptophysin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Immunohistochemical visualization of afferent nerve terminals in human globus pallidus and its alteration in neostriatal neurodegenerative disorders. / Goto, S.; Hirano, A.; Rojas-Corona, R. R.

In: Acta Neuropathologica, Vol. 78, No. 5, 09.1989, p. 543-550.

Research output: Contribution to journalArticle

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