TY - JOUR
T1 - Immunohistochemical Study of the Hippocampus in Parkinsonism-Dementia Complex on Guam
AU - Ito, Hidefumi
AU - Hirano, Asao
AU - Goto, Satoshi
AU - Yen, Shu Hui C.
PY - 1991/7
Y1 - 1991/7
N2 - This investigation concerns the expression of paired helical filaments, tau protein, ubiquitin, β-amyloid protein, and syn aptophysin in the hippocampus of patients with parkinsonism-dementia complex on Guam (PDC) and Alzheimer's dis ease. Alzheimer's neurofibrillary tangles (NFTs) were identified in all cases of PDC and Alzheimer's disease by the modified Bielschowsky method, with which they were readily detected, and by immunohistochemical procedures using antibodies to paired helical filaments, tau protein, and ubiquitin. Observations regarding the different morphological stages indicated that NFTs were similar in PDC and Alzheimer's disease. The same markers were also useful for detecting neuropil threads, abundant in the CA1 field and the subiculum in both diseases. In the CA4 region of some PDC cases, prominent threads were noted. No senile plaques or amyloid angiopathies were seen in the hippocampus of the PDC cases examined. There was a significant decrease in synaptophysin immunoreactivity, most pronounced in the subfield CA1 and the subiculum, as well as in the outer molecular layer of the dentate gyrus, in both disorders. (J Geriatr Psychiatry Neurol 1991;4:134-142).
AB - This investigation concerns the expression of paired helical filaments, tau protein, ubiquitin, β-amyloid protein, and syn aptophysin in the hippocampus of patients with parkinsonism-dementia complex on Guam (PDC) and Alzheimer's dis ease. Alzheimer's neurofibrillary tangles (NFTs) were identified in all cases of PDC and Alzheimer's disease by the modified Bielschowsky method, with which they were readily detected, and by immunohistochemical procedures using antibodies to paired helical filaments, tau protein, and ubiquitin. Observations regarding the different morphological stages indicated that NFTs were similar in PDC and Alzheimer's disease. The same markers were also useful for detecting neuropil threads, abundant in the CA1 field and the subiculum in both diseases. In the CA4 region of some PDC cases, prominent threads were noted. No senile plaques or amyloid angiopathies were seen in the hippocampus of the PDC cases examined. There was a significant decrease in synaptophysin immunoreactivity, most pronounced in the subfield CA1 and the subiculum, as well as in the outer molecular layer of the dentate gyrus, in both disorders. (J Geriatr Psychiatry Neurol 1991;4:134-142).
UR - http://www.scopus.com/inward/record.url?scp=0025737263&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025737263&partnerID=8YFLogxK
U2 - 10.1177/089198879100400303
DO - 10.1177/089198879100400303
M3 - Article
C2 - 1953965
AN - SCOPUS:0025737263
SN - 0891-9887
VL - 4
SP - 134
EP - 142
JO - Journal of Geriatric Psychiatry and Neurology
JF - Journal of Geriatric Psychiatry and Neurology
IS - 3
ER -