Immunohistochemical study of granular cell tumors of the neurohypophysis

Hiroshi Nishioka; Kunio Ii; Josefina F. Llena; Asao Hirano

doi:10.1007/BF02899574

Immunohistochemical study of granular cell tumors of the neurohypophysis

Hiroshi Nishioka, Kunio Ii, Josefina F. Llena, Asao Hirano

Pathology

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35 Scopus citations

Abstract

Six granular cell tumors (GCT) of the neurohypophysis were studied by immunohistochemical techniques. They were all labeled by peanut lectin (Arachis hypogaea) and three showed reactivity for S-100 protein. Unlike extracranial GCT, neuron specific enolase (NSE), myelin basic protein (MBP) and vimentin were not detected in the tumor cells. Glial fibrillary acidic protein (GFAP), keratin and desmin were also not observed. On the other hand, some showed reactivity for alpha-1 -antitrypsin (AAT), alpha-1-antichymotrypsin (AAC) and cathepsin B. These results suggest that neurohypophysial GCT have some features different from extracranial GCT and that they may not be derived from Schwann cells.

Original language	English (US)
Pages (from-to)	413-417
Number of pages	5
Journal	Virchows Archiv B Cell Pathology Including Molecular Pathology
Volume	60
Issue number	1
DOIs	https://doi.org/10.1007/BF02899574
State	Published - Dec 1991

Keywords

Cathepsin B
Granular cell tumor
Immunohistochemistry
Neurohypophysis
Pituicyte

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1007/BF02899574

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title = "Immunohistochemical study of granular cell tumors of the neurohypophysis",

abstract = "Six granular cell tumors (GCT) of the neurohypophysis were studied by immunohistochemical techniques. They were all labeled by peanut lectin (Arachis hypogaea) and three showed reactivity for S-100 protein. Unlike extracranial GCT, neuron specific enolase (NSE), myelin basic protein (MBP) and vimentin were not detected in the tumor cells. Glial fibrillary acidic protein (GFAP), keratin and desmin were also not observed. On the other hand, some showed reactivity for alpha-1 -antitrypsin (AAT), alpha-1-antichymotrypsin (AAC) and cathepsin B. These results suggest that neurohypophysial GCT have some features different from extracranial GCT and that they may not be derived from Schwann cells.",

keywords = "Cathepsin B, Granular cell tumor, Immunohistochemistry, Neurohypophysis, Pituicyte",

author = "Hiroshi Nishioka and Kunio Ii and Llena, {Josefina F.} and Asao Hirano",

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T1 - Immunohistochemical study of granular cell tumors of the neurohypophysis

AU - Nishioka, Hiroshi

AU - Ii, Kunio

AU - Llena, Josefina F.

AU - Hirano, Asao

PY - 1991/12

Y1 - 1991/12

N2 - Six granular cell tumors (GCT) of the neurohypophysis were studied by immunohistochemical techniques. They were all labeled by peanut lectin (Arachis hypogaea) and three showed reactivity for S-100 protein. Unlike extracranial GCT, neuron specific enolase (NSE), myelin basic protein (MBP) and vimentin were not detected in the tumor cells. Glial fibrillary acidic protein (GFAP), keratin and desmin were also not observed. On the other hand, some showed reactivity for alpha-1 -antitrypsin (AAT), alpha-1-antichymotrypsin (AAC) and cathepsin B. These results suggest that neurohypophysial GCT have some features different from extracranial GCT and that they may not be derived from Schwann cells.

AB - Six granular cell tumors (GCT) of the neurohypophysis were studied by immunohistochemical techniques. They were all labeled by peanut lectin (Arachis hypogaea) and three showed reactivity for S-100 protein. Unlike extracranial GCT, neuron specific enolase (NSE), myelin basic protein (MBP) and vimentin were not detected in the tumor cells. Glial fibrillary acidic protein (GFAP), keratin and desmin were also not observed. On the other hand, some showed reactivity for alpha-1 -antitrypsin (AAT), alpha-1-antichymotrypsin (AAC) and cathepsin B. These results suggest that neurohypophysial GCT have some features different from extracranial GCT and that they may not be derived from Schwann cells.

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KW - Pituicyte

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Immunohistochemical study of granular cell tumors of the neurohypophysis

Abstract

Keywords

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