Immunohistochemical study of granular cell tumors of the neurohypophysis

Hiroshi Nishioka, Kunio Ii, Josefina F. Llena, Asao Hirano

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Six granular cell tumors (GCT) of the neurohypophysis were studied by immunohistochemical techniques. They were all labeled by peanut lectin (Arachis hypogaea) and three showed reactivity for S-100 protein. Unlike extracranial GCT, neuron specific enolase (NSE), myelin basic protein (MBP) and vimentin were not detected in the tumor cells. Glial fibrillary acidic protein (GFAP), keratin and desmin were also not observed. On the other hand, some showed reactivity for alpha-1 -antitrypsin (AAT), alpha-1-antichymotrypsin (AAC) and cathepsin B. These results suggest that neurohypophysial GCT have some features different from extracranial GCT and that they may not be derived from Schwann cells.

Original languageEnglish (US)
Pages (from-to)413-417
Number of pages5
JournalVirchows Archiv B Cell Pathology Including Molecular Pathology
Volume60
Issue number1
DOIs
StatePublished - Dec 1991

Fingerprint

Granular Cell Tumor
Posterior Pituitary Gland
Type I Keratin
alpha 1-Antichymotrypsin
Peanut Agglutinin
Cathepsin B
alpha 1-Antitrypsin
Desmin
Myelin Basic Protein
S100 Proteins
Phosphopyruvate Hydratase
Schwann Cells
Glial Fibrillary Acidic Protein
Vimentin
Neoplasms

Keywords

  • Cathepsin B
  • Granular cell tumor
  • Immunohistochemistry
  • Neurohypophysis
  • Pituicyte

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Immunohistochemical study of granular cell tumors of the neurohypophysis. / Nishioka, Hiroshi; Ii, Kunio; Llena, Josefina F.; Hirano, Asao.

In: Virchows Archiv B Cell Pathology Including Molecular Pathology, Vol. 60, No. 1, 12.1991, p. 413-417.

Research output: Contribution to journalArticle

Nishioka, Hiroshi ; Ii, Kunio ; Llena, Josefina F. ; Hirano, Asao. / Immunohistochemical study of granular cell tumors of the neurohypophysis. In: Virchows Archiv B Cell Pathology Including Molecular Pathology. 1991 ; Vol. 60, No. 1. pp. 413-417.
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