Immunohistochemical study of granular cell tumors of the neurohypophysis

Hiroshi Nishioka, Kunio Ii, Josefina F. Llena, Asao Hirano

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35 Scopus citations


Six granular cell tumors (GCT) of the neurohypophysis were studied by immunohistochemical techniques. They were all labeled by peanut lectin (Arachis hypogaea) and three showed reactivity for S-100 protein. Unlike extracranial GCT, neuron specific enolase (NSE), myelin basic protein (MBP) and vimentin were not detected in the tumor cells. Glial fibrillary acidic protein (GFAP), keratin and desmin were also not observed. On the other hand, some showed reactivity for alpha-1 -antitrypsin (AAT), alpha-1-antichymotrypsin (AAC) and cathepsin B. These results suggest that neurohypophysial GCT have some features different from extracranial GCT and that they may not be derived from Schwann cells.

Original languageEnglish (US)
Pages (from-to)413-417
Number of pages5
JournalVirchows Archiv B Cell Pathology Including Molecular Pathology
Issue number1
StatePublished - Dec 1 1991


  • Cathepsin B
  • Granular cell tumor
  • Immunohistochemistry
  • Neurohypophysis
  • Pituicyte

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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