Immunohistochemical changes in morphologically involved and uninvolved colonic mucosa of patients with idiopathic proctitis

K. M. Das, W. F. Erber, Arye Rubinstein

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Alterations in secretory component, IgA, IgG, and IgM were studied by immunofluorescent techniques in mucosal biopsy specimens obtained at colonoscopy from inflamed and grossly uninvolved colonic mucosa from 12 patients with idiopathic proctitis. Parotid salivary secretory component and IgA and serum immunoglobulins were also investigated. Decreased secretory IgA was observed in the epithelium of all grossly involved rectal mucosa and in 40% of proximal normal mucosa. Salivary secretory IgA was not diminished. These observations suggest that a local immune defect may be pathogenetically related to idiopathic proctitis.

Original languageEnglish (US)
Pages (from-to)379-385
Number of pages7
JournalJournal of Clinical Investigation
Volume59
Issue number3
StatePublished - 1977

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Proctitis
Secretory Immunoglobulin A
Mucous Membrane
Secretory Component
Colonoscopy
Immunoglobulin M
Immunoglobulins
Epithelium
Immunoglobulin G
Biopsy
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Immunohistochemical changes in morphologically involved and uninvolved colonic mucosa of patients with idiopathic proctitis. / Das, K. M.; Erber, W. F.; Rubinstein, Arye.

In: Journal of Clinical Investigation, Vol. 59, No. 3, 1977, p. 379-385.

Research output: Contribution to journalArticle

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