TY - JOUR
T1 - Immunoglobulins in defense, pathogenesis, and therapy of fungal diseases
AU - Casadevall, Arturo
AU - Pirofski, Liise Anne
N1 - Funding Information:
A.C. is supported by NIH grants HL059842, AI033774, AI033142, AI052733, and Center for AIDS Research at Albert Einstein College of Medicine. L.P. received support from NIH grants R01-AI045459 and R01-AI044374.
PY - 2012/5/17
Y1 - 2012/5/17
N2 - Only two decades ago antibodies to fungi were thought to have little or no role in protection against fungal diseases. However, subsequent research has provided convincing evidence that certain antibodies can modify the course of fungal infection to the benefit or detriment of the host. Hybridoma technology was the breakthrough that enabled the characterization of antibodies to fungi, illuminating some of the requirements for antibody efficacy. As discussed in this review, fungal-specific antibodies mediate protection through direct actions on fungal cells and through classical mechanisms such as phagocytosis and complement activation. Although mechanisms of antibody-mediated protection are often species-specific, numerous fungal antigens can be targeted to generate vaccines and therapeutic immunoglobulins. Furthermore, the study of antibody function against medically important fungi has provided fresh immunological insights into the complexity of humoral immunity that are likely to apply to other pathogens.
AB - Only two decades ago antibodies to fungi were thought to have little or no role in protection against fungal diseases. However, subsequent research has provided convincing evidence that certain antibodies can modify the course of fungal infection to the benefit or detriment of the host. Hybridoma technology was the breakthrough that enabled the characterization of antibodies to fungi, illuminating some of the requirements for antibody efficacy. As discussed in this review, fungal-specific antibodies mediate protection through direct actions on fungal cells and through classical mechanisms such as phagocytosis and complement activation. Although mechanisms of antibody-mediated protection are often species-specific, numerous fungal antigens can be targeted to generate vaccines and therapeutic immunoglobulins. Furthermore, the study of antibody function against medically important fungi has provided fresh immunological insights into the complexity of humoral immunity that are likely to apply to other pathogens.
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U2 - 10.1016/j.chom.2012.04.004
DO - 10.1016/j.chom.2012.04.004
M3 - Review article
C2 - 22607798
AN - SCOPUS:84861168204
SN - 1931-3128
VL - 11
SP - 447
EP - 456
JO - Cell Host and Microbe
JF - Cell Host and Microbe
IS - 5
ER -