Immunoglobulin M heavy chain disease: Intracellular origin of the Mu chain fragment

Joel Buxbaum; Edward C. Franklin; Matthew D. Scharff

doi:10.1126/science.169.3947.770

Immunoglobulin M heavy chain disease: Intracellular origin of the Mu chain fragment

Joel Buxbaum, Edward C. Franklin, Matthew D. Scharff

Cell Biology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Cells obtained from a patient with mu heavy chain disease synthesize a mu heavy chain fragment with a molecular weight of 55,000. The fragment is detected intracellularly after short labeling times and then is assembled inside the cell and secreted as a disulfide-linked polymer.

Original language	English (US)
Pages (from-to)	770-773
Number of pages	4
Journal	Science
Volume	169
Issue number	3947
DOIs	https://doi.org/10.1126/science.169.3947.770
State	Published - 1970

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title = "Immunoglobulin M heavy chain disease: Intracellular origin of the Mu chain fragment",

abstract = "Cells obtained from a patient with mu heavy chain disease synthesize a mu heavy chain fragment with a molecular weight of 55,000. The fragment is detected intracellularly after short labeling times and then is assembled inside the cell and secreted as a disulfide-linked polymer.",

author = "Joel Buxbaum and Franklin, {Edward C.} and Scharff, {Matthew D.}",

year = "1970",

doi = "10.1126/science.169.3947.770",

language = "English (US)",

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pages = "770--773",

journal = "Science",

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publisher = "American Association for the Advancement of Science",

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T1 - Immunoglobulin M heavy chain disease

T2 - Intracellular origin of the Mu chain fragment

AU - Buxbaum, Joel

AU - Franklin, Edward C.

AU - Scharff, Matthew D.

PY - 1970

Y1 - 1970

N2 - Cells obtained from a patient with mu heavy chain disease synthesize a mu heavy chain fragment with a molecular weight of 55,000. The fragment is detected intracellularly after short labeling times and then is assembled inside the cell and secreted as a disulfide-linked polymer.

AB - Cells obtained from a patient with mu heavy chain disease synthesize a mu heavy chain fragment with a molecular weight of 55,000. The fragment is detected intracellularly after short labeling times and then is assembled inside the cell and secreted as a disulfide-linked polymer.

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DO - 10.1126/science.169.3947.770

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SP - 770

EP - 773

JO - Science

JF - Science

IS - 3947

ER -

Immunoglobulin M heavy chain disease: Intracellular origin of the Mu chain fragment

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