Immunoglobulin M heavy chain disease: Intracellular origin of the Mu chain fragment

Joel Buxbaum, Edward C. Franklin, Matthew D. Scharff

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Cells obtained from a patient with mu heavy chain disease synthesize a mu heavy chain fragment with a molecular weight of 55,000. The fragment is detected intracellularly after short labeling times and then is assembled inside the cell and secreted as a disulfide-linked polymer.

Original languageEnglish (US)
Pages (from-to)770-773
Number of pages4
JournalScience
Volume169
Issue number3947
DOIs
Publication statusPublished - Jan 1 1970

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ASJC Scopus subject areas

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