Immunoglobulin M heavy chain disease: Intracellular origin of the Mu chain fragment

Joel Buxbaum, Edward C. Franklin, Matthew D. Scharff

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Cells obtained from a patient with mu heavy chain disease synthesize a mu heavy chain fragment with a molecular weight of 55,000. The fragment is detected intracellularly after short labeling times and then is assembled inside the cell and secreted as a disulfide-linked polymer.

Original languageEnglish (US)
Pages (from-to)770-773
Number of pages4
JournalScience
Volume169
Issue number3947
StatePublished - 1970

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Heavy Chain Disease
Immunoglobulin Heavy Chains
Immunoglobulin M
Disulfides
Polymers
Molecular Weight

ASJC Scopus subject areas

  • General

Cite this

Immunoglobulin M heavy chain disease : Intracellular origin of the Mu chain fragment. / Buxbaum, Joel; Franklin, Edward C.; Scharff, Matthew D.

In: Science, Vol. 169, No. 3947, 1970, p. 770-773.

Research output: Contribution to journalArticle

Buxbaum, Joel ; Franklin, Edward C. ; Scharff, Matthew D. / Immunoglobulin M heavy chain disease : Intracellular origin of the Mu chain fragment. In: Science. 1970 ; Vol. 169, No. 3947. pp. 770-773.
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