Immunogenetics of autoimmune thyroid diseases: A comprehensive review

Hanna J. Lee, Cheuk Wun Li, Sara Salehi Hammerstad, Mihaela Stefan, Yaron Tomer

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Both environmental and genetic triggers factor into the etiology of autoimmune thyroid disease (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT). Although the exact pathogenesis and causative interaction between environment and genes are unknown, GD and HT share similar immune-mediated mechanisms of disease. They both are characterized by the production of thyroid autoantibodies and by thyroidal lymphocytic infiltration, despite being clinically distinct entities with thyrotoxicosis in GD and hypothyroidism in HT. Family and population studies confirm the strong genetic influence and inheritability in the development of AITD. AITD susceptibility genes can be categorized as either thyroid specific (Tg, TSHR) or immune-modulating (FOXP3, CD25, CD40, CTLA-4, HLA), with HLA-DR3 carrying the highest risk. Of the AITD susceptibility genes, FOXP3 and CD25 play critical roles in the establishment of peripheral tolerance while CD40, CTLA-4, and the HLA genes are pivotal for T lymphocyte activation and antigen presentation. Polymorphisms in these immune-modulating genes, in particular, significantly contribute to the predisposition for GD, HT and, unsurprisingly, other autoimmune diseases. Emerging evidence suggests that single nucleotide polymorphisms (SNPs) in the immunoregulatory genes may functionally hinder the proper development of central and peripheral tolerance and alter T cell interactions with antigen presenting cells (APCs) in the immunological synapse. Thus, susceptibility genes for AITD contribute directly to the key mechanism underlying the development of organ-specific autoimmunity, namely the breakdown in self-tolerance. Here we review the major immune-modulating genes that are associated with AITD and their potential functional effects on thyroidal immune dysregulation.

Original languageEnglish (US)
Article number1811
Pages (from-to)82-90
Number of pages9
JournalJournal of Autoimmunity
Volume64
DOIs
StatePublished - Nov 1 2015
Externally publishedYes

Fingerprint

Immunogenetics
Thyroid Diseases
Autoimmune Diseases
Hashimoto Disease
Graves Disease
Genes
Peripheral Tolerance
Disease Susceptibility
Thyroid Gland
Central Tolerance
Immunological Synapses
HLA-DR3 Antigen
T-Lymphocytes
Self Tolerance
Gene-Environment Interaction
Thyrotoxicosis
Viral Tumor Antigens
Antigen Presentation
Antigen-Presenting Cells
Lymphocyte Activation

Keywords

  • Autoimmune thyroid disease
  • Autoimmunity
  • Graves' disease
  • Hashimoto's thyroiditis
  • Immunogenetics
  • Polymorphism

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Immunogenetics of autoimmune thyroid diseases : A comprehensive review. / Lee, Hanna J.; Li, Cheuk Wun; Hammerstad, Sara Salehi; Stefan, Mihaela; Tomer, Yaron.

In: Journal of Autoimmunity, Vol. 64, 1811, 01.11.2015, p. 82-90.

Research output: Contribution to journalArticle

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