Immunocytochemical study of pituitary oncocytic adenomas

H. Nishioka, H. Ito, A. Hirano, N. Shibata, M. Kobayashi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Using immunocytochemistry we have analyzed 8 pituitary oncocytomas, 14 null cell adenomas, and 2 oncocytomas of the parotid gland (Warthin's tumor). The proportions of adenoma cells that are positive for mitochondrial protein (MP), cytochrome oxidase (COX), and manganese-superoxide dismutase (Mn-SOD) were significantly higher in pituitary oncocytomas than in null cell adenomas (MP P < 0.001, COX P < 0.001, Mn-SOD P < 0.05). In pituitary oncocytomas, MP-positive cells were distributed unevenly but in clusters or in islets admired with some MP-negative cells, and corresponded to COX-positive cells. In contrast, almost all of the oxyphilic epithelial cells of Warthin's tumor were positive for MP, COX, and Mn-SOD. On the other hand, both pituitary tumors displayed similar findings with regard to the proportion of adenoma cells immunoreactive for copper/zinc-SOD and adenohypophysial hormones, the Ki-67 (MIB-1) proliferating cell index, and the mean number of argyrophilic nucleolar organizer regions. It was confirmed that immunocytochemical identification of MP and COX is useful for distinguishing pituitary oncocytomas from null cell adenomas. Although it remains to be determined whether oncocytomas originate from oncocytic changes of tumor cells or from neoplastic transformation of oncocytic cells, it appears that tumorigenesis of pituitary oncocytomas differs from that of Warthin's tumor.

Original languageEnglish (US)
Pages (from-to)42-47
Number of pages6
JournalActa Neuropathologica
Volume94
Issue number1
DOIs
StatePublished - Jul 1997

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Oxyphilic Adenoma
Pituitary Neoplasms
Mitochondrial Proteins
Electron Transport Complex IV
Adenoma
Adenolymphoma
Null Lymphocytes
Neoplastic Cell Transformation
Superoxide Dismutase
Anterior Pituitary Hormones
Nucleolus Organizer Region
Parotid Gland
Zinc
Copper
Carcinogenesis
Epithelial Cells
Immunohistochemistry

Keywords

  • Manganese-superoxide dismutase
  • Mitochondria
  • Null cell adenoma
  • Oncocytomas
  • Pituitary adenoma

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Nishioka, H., Ito, H., Hirano, A., Shibata, N., & Kobayashi, M. (1997). Immunocytochemical study of pituitary oncocytic adenomas. Acta Neuropathologica, 94(1), 42-47. https://doi.org/10.1007/s004010050670

Immunocytochemical study of pituitary oncocytic adenomas. / Nishioka, H.; Ito, H.; Hirano, A.; Shibata, N.; Kobayashi, M.

In: Acta Neuropathologica, Vol. 94, No. 1, 07.1997, p. 42-47.

Research output: Contribution to journalArticle

Nishioka, H, Ito, H, Hirano, A, Shibata, N & Kobayashi, M 1997, 'Immunocytochemical study of pituitary oncocytic adenomas', Acta Neuropathologica, vol. 94, no. 1, pp. 42-47. https://doi.org/10.1007/s004010050670
Nishioka H, Ito H, Hirano A, Shibata N, Kobayashi M. Immunocytochemical study of pituitary oncocytic adenomas. Acta Neuropathologica. 1997 Jul;94(1):42-47. https://doi.org/10.1007/s004010050670
Nishioka, H. ; Ito, H. ; Hirano, A. ; Shibata, N. ; Kobayashi, M. / Immunocytochemical study of pituitary oncocytic adenomas. In: Acta Neuropathologica. 1997 ; Vol. 94, No. 1. pp. 42-47.
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