Immunobiology of acute leukemia

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Amidst the genomic revolution in the characterization of the acute leukemias, immunophenotyping maintains a crucial position in diagnosis, determination of therapy, and monitoring of response to therapy. Lineage determination by multiparameter flow cytometry (MFC), the definition of surrogate marker profiles for genetic lesions which guides molecular analysis towards selective, thus limited, testing, MFC for universal MRD detection, monitoring of specific antigen expression targeted by monoclonal antibodies, and characterization of antigens which are associated with prognostically significant somatic mutations all provide valuable attributes to the comprehensive workup of the acute leukemia patient.

Original languageEnglish (US)
Title of host publicationNeoplastic Diseases of the Blood
PublisherSpringer International Publishing
Pages237-279
Number of pages43
ISBN (Electronic)9783319642635
ISBN (Print)9783319642628
DOIs
StatePublished - Jan 1 2018

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Keywords

  • Flow cytometry
  • Novel classification
  • Surrogate marker acute leukemia subtypes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Paietta, E. M. (2018). Immunobiology of acute leukemia. In Neoplastic Diseases of the Blood (pp. 237-279). Springer International Publishing. https://doi.org/10.1007/978-3-319-64263-5_15