Immunobiology of acute leukemia

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Acute leukemias are commonly defined as the expansion of immature cells that are derived from rare transformed hematopoietic progenitor cells, termed the leukemic stem cells (LSC) or leukemia-initiating cells (LIC), which have the capacity of self-renewal, a defining characteristic also of normal hematopoietic stem cells [1]. As an alternative to originating in a primitive stem cell, leukemias may be derived from transformation of a committed progenitor cell, and, to date, there are well-characterized examples for both concepts among leukemia subtypes. In addition to loss of long-term repopulating potential, also the phenotypic features of the LSC blast cell progeny that invade the bone marrow and the peripheral blood of leukemia patients are different from those of the LSC and typically characterized by different morphology (FAB classification) and antigen profiles. Most interestingly, while the phenotypes of blast cell populations differ based on distinct molecular aberrations, the antigen expression patterns of LSCs for these various subtypes of leukemias, at least in acute myeloid leukemia (AML), are very similar [2].

Original languageEnglish (US)
Title of host publicationNeoplastic Diseases of the Blood
PublisherSpringer New York
Pages241-283
Number of pages43
ISBN (Electronic)9781461437642
ISBN (Print)1461437636, 9781461437635
DOIs
StatePublished - Nov 1 2013

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Keywords

  • Flow cytometry
  • Novel classification
  • Surrogate markers acute leukemia subtypes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Paietta, E. (2013). Immunobiology of acute leukemia. In Neoplastic Diseases of the Blood (pp. 241-283). Springer New York. https://doi.org/10.1007/978-1-4614-3764-2_17