Immune system modulation with LOFU and HIFU treatment of prostate cancer

C. Guha, Z. Huagang, W. Chen, R. Carlosn, N. T. Sanghvi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

High intensity focused ultrasound (HIFU) results in instantaneous coagulative tissue necrosis. In contrast, "low" energy focused ultrasound (LOFU) induces membrane perturbation while maintaining cell viability. This report explores the tumor immunomodulatory roles of LOFU and HIFU combination treatment. We hypothesized that administration of repeated cycles of LOFU, followed by HIFU would release tumor-derived peptide-heat shock protein complexes in the blood and induce systemic tumor-specific immune response that would enhance tumor control of both local and systemic disease.

Original languageEnglish (US)
Title of host publication10th International Symposium on Therapeutic Ultrasound, ISTU 2010
Pages277-282
Number of pages6
DOIs
StatePublished - Oct 13 2011
Event10th International Symposium on Therapeutic Ultrasound, ISTU 2010 - Tokyo, Japan
Duration: Jun 9 2010Jun 12 2010

Publication series

NameAIP Conference Proceedings
Volume1359
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other10th International Symposium on Therapeutic Ultrasound, ISTU 2010
CountryJapan
CityTokyo
Period6/9/106/12/10

Keywords

  • HIFU
  • HSP
  • Immune response
  • LOFU

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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