Immune system modulation with LOFU and HIFU treatment of prostate cancer

C. Guha; Z. Huagang; W. Chen; R. Carlosn; N. T. Sanghvi

doi:10.1063/1.3607918

Immune system modulation with LOFU and HIFU treatment of prostate cancer

C. Guha, Z. Huagang, W. Chen, R. Carlosn, N. T. Sanghvi

Radiation Oncology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

High intensity focused ultrasound (HIFU) results in instantaneous coagulative tissue necrosis. In contrast, "low" energy focused ultrasound (LOFU) induces membrane perturbation while maintaining cell viability. This report explores the tumor immunomodulatory roles of LOFU and HIFU combination treatment. We hypothesized that administration of repeated cycles of LOFU, followed by HIFU would release tumor-derived peptide-heat shock protein complexes in the blood and induce systemic tumor-specific immune response that would enhance tumor control of both local and systemic disease.

Original language	English (US)
Title of host publication	10th International Symposium on Therapeutic Ultrasound, ISTU 2010
Pages	277-282
Number of pages	6
DOIs	https://doi.org/10.1063/1.3607918
State	Published - Oct 13 2011
Event	10th International Symposium on Therapeutic Ultrasound, ISTU 2010 - Tokyo, Japan Duration: Jun 9 2010 → Jun 12 2010

Publication series

Name	AIP Conference Proceedings
Volume	1359
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Other

Other	10th International Symposium on Therapeutic Ultrasound, ISTU 2010
Country/Territory	Japan
City	Tokyo
Period	6/9/10 → 6/12/10

Keywords

HIFU
HSP
Immune response
LOFU

ASJC Scopus subject areas

Physics and Astronomy(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1063/1.3607918

Cite this

Guha, C, Huagang, Z, Chen, W, Carlosn, R & Sanghvi, NT 2011, Immune system modulation with LOFU and HIFU treatment of prostate cancer. in 10th International Symposium on Therapeutic Ultrasound, ISTU 2010. AIP Conference Proceedings, vol. 1359, pp. 277-282, 10th International Symposium on Therapeutic Ultrasound, ISTU 2010, Tokyo, Japan, 6/9/10. https://doi.org/10.1063/1.3607918

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T1 - Immune system modulation with LOFU and HIFU treatment of prostate cancer

AU - Guha, C.

AU - Huagang, Z.

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AU - Carlosn, R.

AU - Sanghvi, N. T.

PY - 2011/10/13

Y1 - 2011/10/13

N2 - High intensity focused ultrasound (HIFU) results in instantaneous coagulative tissue necrosis. In contrast, "low" energy focused ultrasound (LOFU) induces membrane perturbation while maintaining cell viability. This report explores the tumor immunomodulatory roles of LOFU and HIFU combination treatment. We hypothesized that administration of repeated cycles of LOFU, followed by HIFU would release tumor-derived peptide-heat shock protein complexes in the blood and induce systemic tumor-specific immune response that would enhance tumor control of both local and systemic disease.

AB - High intensity focused ultrasound (HIFU) results in instantaneous coagulative tissue necrosis. In contrast, "low" energy focused ultrasound (LOFU) induces membrane perturbation while maintaining cell viability. This report explores the tumor immunomodulatory roles of LOFU and HIFU combination treatment. We hypothesized that administration of repeated cycles of LOFU, followed by HIFU would release tumor-derived peptide-heat shock protein complexes in the blood and induce systemic tumor-specific immune response that would enhance tumor control of both local and systemic disease.

KW - HIFU

KW - HSP

KW - Immune response

KW - LOFU

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BT - 10th International Symposium on Therapeutic Ultrasound, ISTU 2010

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ER -

Immune system modulation with LOFU and HIFU treatment of prostate cancer

Abstract

Publication series

Other

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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