Abstract
High intensity focused ultrasound (HIFU) results in instantaneous coagulative tissue necrosis. In contrast, "low" energy focused ultrasound (LOFU) induces membrane perturbation while maintaining cell viability. This report explores the tumor immunomodulatory roles of LOFU and HIFU combination treatment. We hypothesized that administration of repeated cycles of LOFU, followed by HIFU would release tumor-derived peptide-heat shock protein complexes in the blood and induce systemic tumor-specific immune response that would enhance tumor control of both local and systemic disease.
| Original language | English (US) |
|---|---|
| Title of host publication | AIP Conference Proceedings |
| Pages | 277-282 |
| Number of pages | 6 |
| Volume | 1359 |
| DOIs | |
| State | Published - 2011 |
| Event | 10th International Symposium on Therapeutic Ultrasound, ISTU 2010 - Tokyo, Japan Duration: Jun 9 2010 → Jun 12 2010 |
Other
| Other | 10th International Symposium on Therapeutic Ultrasound, ISTU 2010 |
|---|---|
| Country | Japan |
| City | Tokyo |
| Period | 6/9/10 → 6/12/10 |
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Keywords
- HIFU
- HSP
- Immune response
- LOFU
ASJC Scopus subject areas
- Physics and Astronomy(all)
Cite this
Immune system modulation with LOFU and HIFU treatment of prostate cancer. / Guha, Chandan; Huagang, Z.; Chen, W.; Carlosn, R.; Sanghvi, N. T.
AIP Conference Proceedings. Vol. 1359 2011. p. 277-282.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Immune system modulation with LOFU and HIFU treatment of prostate cancer
AU - Guha, Chandan
AU - Huagang, Z.
AU - Chen, W.
AU - Carlosn, R.
AU - Sanghvi, N. T.
PY - 2011
Y1 - 2011
N2 - High intensity focused ultrasound (HIFU) results in instantaneous coagulative tissue necrosis. In contrast, "low" energy focused ultrasound (LOFU) induces membrane perturbation while maintaining cell viability. This report explores the tumor immunomodulatory roles of LOFU and HIFU combination treatment. We hypothesized that administration of repeated cycles of LOFU, followed by HIFU would release tumor-derived peptide-heat shock protein complexes in the blood and induce systemic tumor-specific immune response that would enhance tumor control of both local and systemic disease.
AB - High intensity focused ultrasound (HIFU) results in instantaneous coagulative tissue necrosis. In contrast, "low" energy focused ultrasound (LOFU) induces membrane perturbation while maintaining cell viability. This report explores the tumor immunomodulatory roles of LOFU and HIFU combination treatment. We hypothesized that administration of repeated cycles of LOFU, followed by HIFU would release tumor-derived peptide-heat shock protein complexes in the blood and induce systemic tumor-specific immune response that would enhance tumor control of both local and systemic disease.
KW - HIFU
KW - HSP
KW - Immune response
KW - LOFU
UR - http://www.scopus.com/inward/record.url?scp=80053652132&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053652132&partnerID=8YFLogxK
U2 - 10.1063/1.3607918
DO - 10.1063/1.3607918
M3 - Conference contribution
AN - SCOPUS:80053652132
SN - 9780735409170
VL - 1359
SP - 277
EP - 282
BT - AIP Conference Proceedings
ER -