Immune system modulation with LOFU and HIFU treatment of prostate cancer

Chandan Guha, Z. Huagang, W. Chen, R. Carlosn, N. T. Sanghvi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

High intensity focused ultrasound (HIFU) results in instantaneous coagulative tissue necrosis. In contrast, "low" energy focused ultrasound (LOFU) induces membrane perturbation while maintaining cell viability. This report explores the tumor immunomodulatory roles of LOFU and HIFU combination treatment. We hypothesized that administration of repeated cycles of LOFU, followed by HIFU would release tumor-derived peptide-heat shock protein complexes in the blood and induce systemic tumor-specific immune response that would enhance tumor control of both local and systemic disease.

Original languageEnglish (US)
Title of host publicationAIP Conference Proceedings
Pages277-282
Number of pages6
Volume1359
DOIs
StatePublished - 2011
Event10th International Symposium on Therapeutic Ultrasound, ISTU 2010 - Tokyo, Japan
Duration: Jun 9 2010Jun 12 2010

Other

Other10th International Symposium on Therapeutic Ultrasound, ISTU 2010
CountryJapan
CityTokyo
Period6/9/106/12/10

Fingerprint

immune systems
tumors
cancer
modulation
energy
necrosis
viability
blood
peptides
shock
membranes
proteins
perturbation
heat
cycles

Keywords

  • HIFU
  • HSP
  • Immune response
  • LOFU

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Guha, C., Huagang, Z., Chen, W., Carlosn, R., & Sanghvi, N. T. (2011). Immune system modulation with LOFU and HIFU treatment of prostate cancer. In AIP Conference Proceedings (Vol. 1359, pp. 277-282) https://doi.org/10.1063/1.3607918

Immune system modulation with LOFU and HIFU treatment of prostate cancer. / Guha, Chandan; Huagang, Z.; Chen, W.; Carlosn, R.; Sanghvi, N. T.

AIP Conference Proceedings. Vol. 1359 2011. p. 277-282.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Guha, C, Huagang, Z, Chen, W, Carlosn, R & Sanghvi, NT 2011, Immune system modulation with LOFU and HIFU treatment of prostate cancer. in AIP Conference Proceedings. vol. 1359, pp. 277-282, 10th International Symposium on Therapeutic Ultrasound, ISTU 2010, Tokyo, Japan, 6/9/10. https://doi.org/10.1063/1.3607918
Guha C, Huagang Z, Chen W, Carlosn R, Sanghvi NT. Immune system modulation with LOFU and HIFU treatment of prostate cancer. In AIP Conference Proceedings. Vol. 1359. 2011. p. 277-282 https://doi.org/10.1063/1.3607918
Guha, Chandan ; Huagang, Z. ; Chen, W. ; Carlosn, R. ; Sanghvi, N. T. / Immune system modulation with LOFU and HIFU treatment of prostate cancer. AIP Conference Proceedings. Vol. 1359 2011. pp. 277-282
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