Immune recognition of influenza virus haemagglutinin.

J. J. Skehel, B. C. Barnet, D. S. Burt, R. S. Daniels, A. R. Douglas, C. M. Graham, J. Hodgson, M. Knossow, K. H. Mills, P. F. Riska

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Abstract

Haemagglutinin glycoproteins are the components of influenza virus membranes against which infectivity-neutralizing antibodies are directed. Sequence analysis of natural and laboratory-selected variant haemagglutinins indicates the regions of the molecule recognized by antibodies and by helper T cells; the identity of these regions and the relations between them are discussed.

Original languageEnglish (US)
Pages (from-to)479-483; discussion 483-485
JournalPhilosophical transactions of the Royal Society of London. Series B, Biological sciences
Volume323
Issue number1217
StatePublished - Jun 12 1989
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Skehel, J. J., Barnet, B. C., Burt, D. S., Daniels, R. S., Douglas, A. R., Graham, C. M., Hodgson, J., Knossow, M., Mills, K. H., & Riska, P. F. (1989). Immune recognition of influenza virus haemagglutinin. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 323(1217), 479-483; discussion 483-485.