Immune evasion by Mycobacterium tuberculosis: Living with the enemy

Jo Anne L. Flynn, John Chan

Research output: Contribution to journalReview article

215 Scopus citations

Abstract

Mycobacterium tuberculosis is successful as a pathogen because of its ability to persist in an immunocompetent host. This bacterium lives within the macrophage, a cell whose function is the elimination of microbes. Recent advances have improved our understanding of how M. tuberculosis evades two major antimicrobial mechanisms of macrophages: phagolysosome fusion and the production of toxic reactive nitrogen intermediates. M. tuberculosis also modulates antigen presentation to prevent the detection of infected macrophages by CD4+ T cells.

Original languageEnglish (US)
Pages (from-to)450-455
Number of pages6
JournalCurrent Opinion in Immunology
Volume15
Issue number4
DOIs
StatePublished - Jun 2003

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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