Immune Dysregulation in the Pathogenesis of Atopic Dermatitis

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Atopic dermatitis is a multifactorial disease. Epidermal barrier impairment often plays the initial role in the initiation of the disease. Immune dysregulation of the innate and adaptive immunity plays a central role in the pathogenesis of atopic dermatitis. Alteration of the epidermal microbiome-host interaction serves a catalytic role in propagating this immune response. The understanding of this disease pathogenesis is important in generating treatment options, especially those such as biologic agents that can target a specific immune pathway.

Original languageEnglish (US)
Pages (from-to)57-62
Number of pages6
JournalDermatitis
Volume29
Issue number2
DOIs
StatePublished - Mar 1 2018

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Dermatology

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