Immune Complexes in Pediatric Human Immunodeficiency Virus Infection

Maadhava Ellaurie, Theresa Calvelli, Arye Rubinstein

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Circulating immune complexes (CIC) were analyzed in a cohort of 30 children infected with the human immunodeficiency virus. Elevated CIC were detected by the C1 q assay in 70% (21/30) of all patients and by the Raji cell assay in 93% (28/30) of all patients. While only less than one third of patients with elevated CIC had free serum antibodies to Epstein-Barr virus, 80% (16/20) of them had detectable antibodies to Epstein-Barr virus associated with CIC. Enriched CIC in human immunodeficiency virus–infected children contained low levels of complement. These findings document that, as an expression of the humoral immunodeficiency, CIC in human immunodeficiency virus–infected children are deficient in complement and can thus be underestimated if complement-precipitating methods are used for their detection.

Original languageEnglish (US)
Pages (from-to)1207-1209
Number of pages3
JournalAmerican Journal of Diseases of Children
Volume144
Issue number11
DOIs
StatePublished - 1990

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Virus Diseases
Antigen-Antibody Complex
HIV
Pediatrics
Human Herpesvirus 4
Antibodies
Serum

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Immune Complexes in Pediatric Human Immunodeficiency Virus Infection. / Ellaurie, Maadhava; Calvelli, Theresa; Rubinstein, Arye.

In: American Journal of Diseases of Children, Vol. 144, No. 11, 1990, p. 1207-1209.

Research output: Contribution to journalArticle

Ellaurie, Maadhava ; Calvelli, Theresa ; Rubinstein, Arye. / Immune Complexes in Pediatric Human Immunodeficiency Virus Infection. In: American Journal of Diseases of Children. 1990 ; Vol. 144, No. 11. pp. 1207-1209.
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