Immune complex-mediated renal involvement in relapsing polychondritis

Luis R. Espinoza, Alan Richman, Tomas Bocanegra, Iliana Pina, Frank B. Vasey, Stephen I. Rifkin, Bernard F. Germain

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Abstract

A patient with relapsing polychondritis who presented with rapidly progressive glomerulonephritis is described. This is the fourth case in which this association is reported. Crescentic glomerulonephritis was found on renal biopsy. Evidence for immunologic participation in the pathogenesis of this condition is suggested by the demonstration of circulating immune complexes, immunoglobulin and complement deposition by immunofluorescence, and electron dense deposits by electron microscopy of the kidney. Favorable response followed therapy with prednisone and dapsone.

Original languageEnglish (US)
Pages (from-to)181-183
Number of pages3
JournalThe American Journal of Medicine
Volume71
Issue number1
DOIs
StatePublished - Jul 1981

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ASJC Scopus subject areas

  • Medicine(all)

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Espinoza, L. R., Richman, A., Bocanegra, T., Pina, I., Vasey, F. B., Rifkin, S. I., & Germain, B. F. (1981). Immune complex-mediated renal involvement in relapsing polychondritis. The American Journal of Medicine, 71(1), 181-183. https://doi.org/10.1016/0002-9343(81)90291-6