Immune cells as targets for cardioprotection: New players and novel therapeutic opportunities

Ioanna Andreadou, Hector A. Cabrera-Fuentes, Yvan Devaux, Nikolaos G. Frangogiannis, Stefan Frantz, Tomasz Guzik, Elisa A. Liehn, Clarissa P.C. Gomes, Rainer Schulz, Derek J. Hausenloy

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

New therapies are required to reduce myocardial infarct (MI) size and prevent the onset of heart failure in patients presenting with acute myocardial infarction (AMI), one of the leading causes of death and disability globally. In this regard, the immune cell response to AMI, which comprises an initial pro-inflammatory reaction followed by an anti-inflammatory phase, contributes to final MI size and post-AMI remodelling [changes in left ventricular (LV) size and function]. The transition between these two phases is critical in this regard, with a persistent and severe pro-inflammatory reaction leading to adverse LV remodelling and increased propensity for developing heart failure. In this review article, we provide an overview of the immune cells involved in orchestrating the complex and dynamic inflammatory response to AMI-these include neutrophils, monocytes/macrophages, and emerging players such as dendritic cells, lymphocytes, pericardial lymphoid cells, endothelial cells, and cardiac fibroblasts. We discuss potential reasons for past failures of anti-inflammatory cardioprotective therapies, and highlight new treatment targets for modulating the immune cell response to AMI, as a potential therapeutic strategy to improve clinical outcomes in AMI patients. This article is part of a Cardiovascular Research Spotlight Issue entitled 'Cardioprotection Beyond the Cardiomyocyte', and emerged as part of the discussions of the European Union (EU)-CARDIOPROTECTION Cooperation in Science and Technology (COST) Action, CA16225.

Original languageEnglish (US)
Pages (from-to)1117-1130
Number of pages14
JournalCardiovascular research
Volume115
Issue number7
DOIs
StatePublished - Jun 1 2019

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Keywords

  • Acute myocardial infarction
  • Dendritic cells
  • Fibroblasts
  • Inflammation
  • Lymphocytes
  • Macrophages
  • Monocytes
  • Myocardial ischaemia/reperfusion injury

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Andreadou, I., Cabrera-Fuentes, H. A., Devaux, Y., Frangogiannis, N. G., Frantz, S., Guzik, T., Liehn, E. A., Gomes, C. P. C., Schulz, R., & Hausenloy, D. J. (2019). Immune cells as targets for cardioprotection: New players and novel therapeutic opportunities. Cardiovascular research, 115(7), 1117-1130. https://doi.org/10.1093/cvr/cvz050