TY - JOUR
T1 - Immediate life support by a single transplanted lung in puppies
AU - Veith, Frank J.
AU - Richards, Kenneth
AU - Boley, Scott J.
N1 - Funding Information:
Supported in part by grants from the U.S. Public Health Service (HE 11472, HE 11567), the Health Research Council of the City of New York, the American Heart Association, the National Tuberculosis and Respiratory Disease Association, the Markle Foundation, and the Manning Foundation.
PY - 1970/4
Y1 - 1970/4
N2 - Lung allotransplantation followed immediately by ligation of the opposite pulmonary artery is compatible with survival for at least eight days in 5-10-Kg. puppies if the arterial anastomosis is made distensible and if there are no other technical flaws. The denervated transplanted lung does not necessarily develop congestion, hemorrhage or edema even though it is providing adequate total gas exchange while carrying the entire cardiac output. Technical problems, which are more difficult to prevent in puppies than in adult dogs, can be over-come by suitable precautions. Presently available immunosuppression is insufficient to prevent significant rejection of transplanted lungs with certainty in an outbred population. Ultimately, however, as improved methods for preventing rejection are developed, lung transplantation, as a therapeutic modality, should be feasible in infants and children.
AB - Lung allotransplantation followed immediately by ligation of the opposite pulmonary artery is compatible with survival for at least eight days in 5-10-Kg. puppies if the arterial anastomosis is made distensible and if there are no other technical flaws. The denervated transplanted lung does not necessarily develop congestion, hemorrhage or edema even though it is providing adequate total gas exchange while carrying the entire cardiac output. Technical problems, which are more difficult to prevent in puppies than in adult dogs, can be over-come by suitable precautions. Presently available immunosuppression is insufficient to prevent significant rejection of transplanted lungs with certainty in an outbred population. Ultimately, however, as improved methods for preventing rejection are developed, lung transplantation, as a therapeutic modality, should be feasible in infants and children.
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U2 - 10.1016/0022-3468(70)90282-4
DO - 10.1016/0022-3468(70)90282-4
M3 - Article
C2 - 4911480
AN - SCOPUS:0014776145
SN - 0022-3468
VL - 5
SP - 244
EP - 250
JO - Journal of Pediatric Surgery
JF - Journal of Pediatric Surgery
IS - 2
ER -