Abstract
Continued interest in imino-sugar nucleosides derives from the observations that N-ribosyltransferases are powerfully inhibited by imino-C-nucleoside analogues that mimic the ribooxacarbenium ion nature of their transition states. The synthesis of such compounds is challenging, and synthetic routes to imino- and imino-C-nucleosides are reviewed, together with the nature of the N-ribosyltransferases that are targets for these analogues. Examples are given to exemplify the promise these compounds hold for the treatments of biological disorders.
Original language | English (US) |
---|---|
Pages (from-to) | 525-540 |
Number of pages | 16 |
Journal | Current topics in medicinal chemistry |
Volume | 3 |
Issue number | 5 |
DOIs | |
State | Published - 2003 |
ASJC Scopus subject areas
- Drug Discovery