Imino-sugar-based nucleosides.

Vern L. Schramm, Peter C. Tyler

Research output: Contribution to journalReview article

52 Scopus citations

Abstract

Continued interest in imino-sugar nucleosides derives from the observations that N-ribosyltransferases are powerfully inhibited by imino-C-nucleoside analogues that mimic the ribooxacarbenium ion nature of their transition states. The synthesis of such compounds is challenging, and synthetic routes to imino- and imino-C-nucleosides are reviewed, together with the nature of the N-ribosyltransferases that are targets for these analogues. Examples are given to exemplify the promise these compounds hold for the treatments of biological disorders.

Original languageEnglish (US)
Pages (from-to)525-540
Number of pages16
JournalCurrent topics in medicinal chemistry
Volume3
Issue number5
DOIs
StatePublished - 2003

ASJC Scopus subject areas

  • Drug Discovery

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